I perform GSEA only on the epiblast samples, since the extraembryonic halves did not show measurable differential expression.
1 Gene Set Enrichment Test
| ID | Description | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalues | rank | leading_edge | core_enrichment | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007389 | GO:0007389 | pattern specification process | 298 | -0.4539305 | -1.875649 | 0.0000000 | 0.0000086 | 0.0000077 | 1409 | tags=23%, list=11%, signal=21% | Gorab/Bmpr1a/Ror2/Ap1b1/Pcsk5/Gpc3/Pbx2/Cyp26a1/Crb2/Hes1/Xrcc2/Reln/Cfc1/Tgfbr2/Tmed2/Aurka/Mns1/Meis3/Gpr161/Plxna2/Pcdh8/Gata4/Sp8/Intu/Eed/Fgf3/Hhex/Egr2/Foxa2/Acvr1/Bmp2/Foxa1/Grsf1/Pbx1/Hspb11/Msx2/Dll1/Nme7/Frat1/Wnt2/Gsc/Foxj1/Ctnnbip1/Lfng/Lhx1/Wls/Aplnr/Eomes/Ifitm1/Smad6/Alg5/Meis2/Mesp1/Snai1/Fst/Tdgf1/Gas1/Dll3/Cer1/T/Msx1/Efnb1/Wnt3/Zeb2/Cyp26c1/Wnt5a/Aida/Mesp2/Bmp7 |
| GO:0044728 | GO:0044728 | DNA methylation or demethylation | 72 | 0.6235490 | 2.183376 | 0.0000001 | 0.0000726 | 0.0000652 | 1234 | tags=32%, list=10%, signal=29% | Tet1/Dnmt3a/Grhl2/Dnmt3l/Meg3/Tdrd12/Gnasas1/Bend3/Dnmt3b/Kmt2a/Usp7/Tet3/Baz2a/Atf7ip/Pld6/Apobec3/Ftx/Fkbp6/Parp1/Fto/Apobec2/Ehmt1/Mael |
| GO:0001707 | GO:0001707 | mesoderm formation | 49 | -0.7041455 | -2.274485 | 0.0000001 | 0.0000726 | 0.0000652 | 545 | tags=31%, list=4%, signal=29% | Pofut2/Acvr1/Wls/Epha2/Hmga2/Eomes/Mesp1/Snai1/T/Wnt3/Smad1/Etv2/Wnt5a/Mesp2/Bmp7 |
| GO:0007507 | GO:0007507 | heart development | 452 | -0.3948874 | -1.693752 | 0.0000001 | 0.0000726 | 0.0000652 | 1577 | tags=21%, list=12%, signal=19% | Id3/Zmpste24/Tsc1/Tmem67/Prox1/Hexim1/Bmpr1a/Cpe/Tgfbr3/Slc25a4/Ap1b1/Apela/Id2/Pcsk5/Gpc3/Gsk3b/Hes1/Pkd1/Tmem65/Adamts9/Tpm1/Efnb2/Slit2/Cfc1/Sec24b/Fzd2/Ramp2/Ccn1/Tgfbr2/Tmed2/Gna11/Sin3b/Vcan/Ripk1/Emilin1/Efna1/Ncam1/Chd7/Gata4/Heg1/Cacybp/Dlc1/Adam19/Tenm4/Hdac2/Pdlim4/Ndufv2/Lmo4/Fgf3/Hhex/Fzd1/Jag1/Atg5/Thbs1/Acvr1/Bmp2/Tnfrsf1b/Hspb11/Kdr/Pkp2/Rac1/Cdc42/Gjc1/Msx2/Ptcd2/Dsg2/Dll1/Dusp6/Wnt2/Apln/Foxj1/Spred1/Fn1/Aplnr/Eomes/Smad6/Pdgfra/Jun/Rbp4/Tnfrsf1a/Mesp1/Snai1/Tdgf1/Cer1/T/Msx1/Mixl1/Smad1/Wnt5a/Mesp2/Id1/Gata6/Bmp7 |
| GO:0048729 | GO:0048729 | tissue morphogenesis | 479 | -0.3870664 | -1.661951 | 0.0000001 | 0.0000726 | 0.0000652 | 1659 | tags=22%, list=13%, signal=20% | Cited2/Prickle1/Cited1/Rhoa/Phldb2/Clasp2/Pdgfa/Tsc1/Tmem67/Prox1/Slc12a2/Gorab/Ctsh/Bmpr1a/Ror2/Six4/Tgfbr3/Rhob/Gpc3/Actg1/Twsg1/Crb2/Hes1/Exoc5/Pkd1/Tpm1/Efnb2/Chuk/Slit2/Rreb1/Socs3/Wnk4/Map3k7/Cfc1/Sec24b/Fzd2/Ccn1/Enah/Ctsl/Tgfbr2/Tmed2/Epha4/Rock2/Rala/Pcdh8/Zdhhc7/Chd7/Gata4/Heg1/Ctsz/Gcnt1/Dlc1/Intu/Nkd1/Lmo4/Fgf3/Coq7/Pofut2/Hhex/Fzd1/Pdcd10/Jag1/Foxa2/Acvr1/Ntn1/Bmp2/Actb/Foxa1/Bcl10/Grsf1/Pbx1/Kdr/Pkp2/Rac1/Cdc42/Msx2/Ptcd2/Dll1/Wnt2/Znrf3/Ctnnbip1/Dact1/Lhx1/Wls/Ipmk/Aplnr/Epha2/Hmga2/Eomes/Pdgfra/Ret/Lgr5/Mesp1/Snai1/Fst/T/Msx1/Wnt3/Smad1/Frzb/Zeb2/Etv2/Wnt5a/Klf4/Mesp2/Bmp7 |
| GO:0048332 | GO:0048332 | mesoderm morphogenesis | 53 | -0.6749339 | -2.216379 | 0.0000001 | 0.0000726 | 0.0000652 | 545 | tags=28%, list=4%, signal=27% | Pofut2/Acvr1/Wls/Epha2/Hmga2/Eomes/Mesp1/Snai1/T/Wnt3/Smad1/Etv2/Wnt5a/Mesp2/Bmp7 |
| GO:0034113 | GO:0034113 | heterotypic cell-cell adhesion | 33 | -0.7568912 | -2.243687 | 0.0000002 | 0.0001057 | 0.0000948 | 1166 | tags=39%, list=9%, signal=36% | Apoa1/Ninj1/Myadm/Itgav/Fgg/Pkp2/Fga/Dsg2/Fgb/Alox15/Itgb7/Klf4/Bmp7 |
| GO:1902895 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 36 | -0.7315791 | -2.210510 | 0.0000003 | 0.0001112 | 0.0000998 | 466 | tags=22%, list=4%, signal=21% | Bmp2/Egr1/Apln/Smad6/Jun/Smad1/Klf4/Fos |
| GO:0043549 | GO:0043549 | regulation of kinase activity | 493 | -0.3736929 | -1.613949 | 0.0000006 | 0.0002293 | 0.0002058 | 2307 | tags=25%, list=18%, signal=21% | Flt1/Prkca/Met/Cops8/Sash1/Chordc1/Slc9a3r1/Erbb2/Fbn1/Pfkfb1/Cacul1/Cib1/Tpd52l1/Pak1/Osbpl8/Snx9/Macroh2a1/Sdc4/Map2k2/Rtraf/Map2k4/Sh3bp5l/Fam72a/Fgfr1/Pih1d1/Ryk/Lats2/Ccnb2/Mmd/Calca/Ccnjl/Chp1/Rhoa/Dbndd1/Pdgfa/Dusp22/Tsc1/Tfap4/Prox1/Npm1/Bccip/Ralb/Pkia/Hexim1/Psmd10/Camk1/Fzd10/Zfp91/Marcks/Ror2/Dusp12/Dusp10/Gsk3b/Prkag1/Cdk5/Traf4/Pkd1/Ccnl1/Hnf4a/Map3k7/Tsg101/Reln/Sh2b3/Ccn1/Tgfbr2/Fzd4/Ccnyl1/Epha4/Apoe/Rap2c/Dstyk/Efna1/Ccne2/Heg1/Cab39/Ptpn2/Uvrag/Prdx3/Zfp622/Lmo4/Rap1a/Pmp22/Malt1/Hhex/Ezh2/Ccny/Pdcd10/Cdkn2d/Foxa2/Dtnbp1/Thbs1/Ceacam1/Bmp2/Actb/Bad/Tigar/Kdr/Rac1/Cdc42/Ccni/Nbn/Egr1/Ankrd54/Ccnh/Dnaja1/Spred1/Sh3glb1/Ccnd2/Epha2/Hmga2/Strada/Pdgfra/Ret/Pkig/Cd24a/Hipk3/Tdgf1/Adra2b/Dusp1/Zeb2/Wnt5a/Aida/Bmp7 |
| GO:0007178 | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 262 | -0.4377542 | -1.781010 | 0.0000006 | 0.0002293 | 0.0002058 | 1659 | tags=23%, list=13%, signal=21% | Cited2/Tob1/Zyx/Cited1/Ppm1a/Strap/Dusp22/Slc39a5/Afp/Bmpr1a/Ror2/Tgfbr3/Apela/Gpc3/Hspa5/Twsg1/Pelo/Crb2/Hes1/Hexa/Hnf4a/Xbp1/Map3k7/Cfc1/Ccn1/Inhbc/Tgfbr2/Fbn2/Emilin1/Bambi/Gata4/Sub1/Trf/Nrep/Fzd1/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Kdr/Msx2/Egr1/Zfp703/Spred1/Lefty2/Smad6/Jun/Fst/Tdgf1/Cer1/T/Msx1/Smad1/Zeb2/Etv2/Wnt5a/Id1/Gata6/Bmp7/Fos |
| GO:0048738 | GO:0048738 | cardiac muscle tissue development | 168 | -0.4796339 | -1.869717 | 0.0000008 | 0.0002817 | 0.0002528 | 2032 | tags=29%, list=16%, signal=25% | Cdk1/Pak1/Hey1/Map2k4/Fgfr1/Tomm70a/Cited2/Zmpste24/Tsc1/Prox1/Bmpr1a/Tgfbr3/Slc25a4/Id2/Gsk3b/Adamts9/Tpm1/Efnb2/Tgfbr2/Sin3b/Ripk1/Ncam1/Chd7/Gata4/Heg1/Cacybp/Tenm4/Hdac2/Ndufv2/Fgf3/Atg5/Acvr1/Bmp2/Pkp2/Cdc42/Gjc1/Ptcd2/Dsg2/Dll1/Wnt2/Pdgfra/Rbp4/Mesp1/Tdgf1/T/Smad1/Wnt5a/Gata6/Bmp7 |
| GO:0060537 | GO:0060537 | muscle tissue development | 288 | -0.4252584 | -1.751287 | 0.0000015 | 0.0004571 | 0.0004102 | 2032 | tags=26%, list=16%, signal=22% | Cdk1/Pak1/Hey1/Foxn2/Map2k4/Cops2/Fgfr1/Stra6/Tomm70a/Mtm1/Efemp2/Cited2/Rhoa/Hlf/Zmpste24/Tsc1/Cfl2/Prox1/Bmpr1a/Six4/Tgfbr3/Slc25a4/Id2/Srpk3/Gsk3b/Cdk5/Adamts9/Tpm1/Efnb2/Med20/Tgfbr2/Mettl8/Atf3/Sin3b/Ripk1/Ifrd1/Ncam1/Chd7/Gata4/Heg1/Cacybp/Zfand5/Psma6/Tenm4/Hdac2/Ndufv2/Fgf3/Pmp22/Egr2/Atg5/Acvr1/Bmp2/Pkp2/Cdc42/Gjc1/Ptcd2/Dsg2/Dll1/Egr1/Wnt2/Eomes/Pdgfra/Rbp4/Mesp1/Tiparp/Tdgf1/Rcan1/T/Smad1/Wnt5a/Tsc22d3/Gata6/Bmp7/Fos |
| GO:0070848 | GO:0070848 | response to growth factor | 459 | -0.3689336 | -1.579582 | 0.0000034 | 0.0008150 | 0.0007315 | 1895 | tags=20%, list=15%, signal=18% | Bmper/Fgfr1/Cd63/Lats2/Bmpr1b/Bmpr2/Rock1/Pbld1/Calca/Cited2/Tob1/Zyx/Cited1/Lgmn/Wasf1/Ppm1a/Strap/Dusp22/Slc39a5/Pdcd6/Ndn/Tspan12/Bmpr1a/Ror2/Tgfbr3/Fgfbp1/Gpc3/Hspa5/Twsg1/Gsk3b/Pelo/Crb2/Hes1/Rasa1/Uri1/Slit2/Xbp1/Map3k7/Fgf17/Ramp2/Pik3ca/Ccn1/Adgra2/Tgfbr2/Fzd4/Fbn2/Rock2/Dstyk/Ripk1/Emilin1/Sort1/Tbc1d7/Bambi/Gata4/Pde8a/Nrep/Rap1a/Fgf3/Hhex/Fzd1/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Kdr/Arpc2/Msx2/Dll1/Egr1/Ier2/Zfp703/Nptn/Apln/Spred1/Sh3glb1/Lefty2/Epha2/Smad6/Pdgfra/Jun/Fst/Tdgf1/Cer1/Msx1/Smad1/Zeb2/Etv2/Wnt5a/Klf4/Id1/Gata6/Bmp7/Fos |
| GO:0001568 | GO:0001568 | blood vessel development | 495 | -0.3674683 | -1.585272 | 0.0000034 | 0.0008150 | 0.0007315 | 1796 | tags=22%, list=14%, signal=19% | Ddit3/Bmpr2/Rock1/Efemp2/Cdh2/Glmn/Hmgb1/Cited2/Prickle1/Cited1/Rhoa/Pdgfa/S100a1/Prox1/Mydgf/Pdcd6/Tspan12/Slc12a2/Ctsh/Bmpr1a/Tgfbr3/Apela/Pcsk5/Fgfbp1/Rhob/Gpc3/Actg1/Hes1/Qk/Rasa1/Pkd1/Adamts9/Efnb2/Slit2/Socs3/Ywhaz/Xbp1/Map3k7/Cfc1/Sec24b/Sh2b3/Ets1/Ninj1/Ramp2/Pik3ca/Ccn1/Pdcl3/Adgra2/Tgfbr2/Ppp1r15a/Fzd4/Tmed2/Apoe/Rock2/Efna3/Emilin1/Emc10/Efna1/Chd7/Gata4/Heg1/Itgav/Ptger4/Rap1a/Naa15/Hhex/Ppp1r16b/Pdcd10/Jag1/Cx3cl1/Egr2/Fmnl3/Thbs1/Acvr1/Ceacam1/Kdr/Cdc42/Gjc1/Dll1/Egr1/Wnt2/Apln/Aimp1/Spred1/Arhgap22/Fn1/Aplnr/Epha2/Hmga2/Anpep/Smad6/Pdgfra/Jun/Tnfrsf1a/Mesp1/Tiparp/Tdgf1/T/Adra2b/Smad1/Etv2/Wnt5a/Klf4/Id1/Gata6/Bmp7/Asb4 |
| GO:0060411 | GO:0060411 | cardiac septum morphogenesis | 66 | -0.6276051 | -2.154390 | 0.0000035 | 0.0008150 | 0.0007315 | 1990 | tags=38%, list=15%, signal=32% | Hey1/Dnah11/Bmpr2/Cited2/Prox1/Bmpr1a/Tgfbr3/Id2/Hes1/Slit2/Cfc1/Fzd2/Ccn1/Tgfbr2/Chd7/Gata4/Fzd1/Jag1/Acvr1/Msx2/Aplnr/Smad6/Wnt5a/Gata6/Bmp7 |
| GO:0006306 | GO:0006306 | DNA methylation | 58 | 0.6265708 | 2.125992 | 0.0000038 | 0.0008150 | 0.0007315 | 1234 | tags=33%, list=10%, signal=30% | Tet1/Dnmt3a/Grhl2/Dnmt3l/Meg3/Tdrd12/Gnasas1/Bend3/Dnmt3b/Kmt2a/Tet3/Baz2a/Atf7ip/Pld6/Ftx/Fkbp6/Parp1/Ehmt1/Mael |
| GO:0071900 | GO:0071900 | regulation of protein serine/threonine kinase activity | 248 | -0.4241421 | -1.719451 | 0.0000038 | 0.0008150 | 0.0007315 | 2015 | tags=25%, list=16%, signal=22% | Tpd52l1/Pak1/Macroh2a1/Map2k2/Map2k4/Fgfr1/Pih1d1/Lats2/Ccnb2/Ccnjl/Rhoa/Pdgfa/Tfap4/Prox1/Bccip/Ralb/Pkia/Hexim1/Psmd10/Camk1/Fzd10/Marcks/Ror2/Dusp10/Gsk3b/Prkag1/Pkd1/Ccnl1/Map3k7/Tsg101/Sh2b3/Fzd4/Epha4/Apoe/Ccne2/Heg1/Cab39/Uvrag/Pmp22/Hhex/Ezh2/Ccny/Pdcd10/Cdkn2d/Dtnbp1/Thbs1/Ceacam1/Bmp2/Actb/Ccni/Ccnh/Dnaja1/Ccnd2/Hmga2/Pkig/Cd24a/Hipk3/Tdgf1/Dusp1/Zeb2/Wnt5a/Aida/Bmp7 |
| GO:0048514 | GO:0048514 | blood vessel morphogenesis | 422 | -0.3747623 | -1.598523 | 0.0000040 | 0.0008150 | 0.0007315 | 1786 | tags=22%, list=14%, signal=20% | Bmpr2/Rock1/Efemp2/Cdh2/Glmn/Hmgb1/Cited2/Cited1/Rhoa/Pdgfa/S100a1/Prox1/Mydgf/Pdcd6/Tspan12/Slc12a2/Ctsh/Bmpr1a/Tgfbr3/Apela/Fgfbp1/Rhob/Actg1/Hes1/Qk/Rasa1/Adamts9/Efnb2/Slit2/Ywhaz/Xbp1/Map3k7/Sec24b/Sh2b3/Ets1/Ninj1/Ramp2/Pik3ca/Ccn1/Pdcl3/Adgra2/Tgfbr2/Ppp1r15a/Fzd4/Apoe/Rock2/Efna3/Emilin1/Emc10/Efna1/Chd7/Gata4/Heg1/Itgav/Ptger4/Rap1a/Naa15/Hhex/Ppp1r16b/Pdcd10/Jag1/Cx3cl1/Fmnl3/Thbs1/Acvr1/Ceacam1/Kdr/Cdc42/Gjc1/Dll1/Apln/Aimp1/Spred1/Arhgap22/Fn1/Aplnr/Epha2/Hmga2/Anpep/Smad6/Pdgfra/Jun/Tnfrsf1a/Tiparp/Tdgf1/T/Adra2b/Smad1/Etv2/Wnt5a/Klf4/Id1/Gata6/Asb4 |
| GO:0003007 | GO:0003007 | heart morphogenesis | 192 | -0.4583796 | -1.819573 | 0.0000046 | 0.0008950 | 0.0008033 | 1394 | tags=22%, list=11%, signal=20% | Bmpr1a/Cpe/Tgfbr3/Id2/Hes1/Tpm1/Slit2/Cfc1/Sec24b/Fzd2/Ccn1/Tgfbr2/Tmed2/Efna1/Chd7/Gata4/Heg1/Dlc1/Fzd1/Jag1/Thbs1/Acvr1/Bmp2/Pkp2/Rac1/Cdc42/Msx2/Ptcd2/Dll1/Wnt2/Aplnr/Smad6/Jun/Rbp4/Mesp1/Snai1/T/Msx1/Wnt5a/Mesp2/Gata6/Bmp7 |
| GO:0007498 | GO:0007498 | mesoderm development | 93 | -0.5517108 | -1.984711 | 0.0000058 | 0.0010571 | 0.0009488 | 545 | tags=23%, list=4%, signal=22% | Pofut2/Foxa2/Acvr1/Mesd/Lhx1/Wls/Epha2/Hmga2/Eomes/Mesp1/Snai1/Dll3/Cer1/T/Mixl1/Wnt3/Smad1/Etv2/Wnt5a/Mesp2/Bmp7 |
| GO:0061614 | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 49 | -0.6521915 | -2.106667 | 0.0000059 | 0.0010571 | 0.0009488 | 613 | tags=20%, list=5%, signal=20% | Hdac2/Bmp2/Egr1/Apln/Smad6/Jun/Smad1/Klf4/Gata6/Fos |
| GO:0060485 | GO:0060485 | mesenchyme development | 207 | -0.4441250 | -1.779361 | 0.0000060 | 0.0010571 | 0.0009488 | 1789 | tags=27%, list=14%, signal=24% | Glipr2/Bmpr2/Rock1/Cdh2/Sdhaf2/Cited2/Phldb2/Clasp2/Pdcd6/Bmpr1a/Six4/Tgfbr3/Gsk3b/Cyp26a1/Crb2/Hes1/Tgfbr2/Adipor1/Hpn/Rock2/Efna1/Bambi/Gata4/Hdac2/Mcrip1/Pofut2/Ezh2/Jag1/Sdcbp/Foxa2/Thbs1/Acvr1/Bmp2/Foxa1/Cdc42/Msx2/Zfp703/Wnt2/Gsc/Spred1/Fn1/Aplnr/Hmga2/Eomes/Ret/Mesp1/Snai1/Dll3/Cer1/Msx1/Efnb1/Frzb/Zeb2/Cyp26c1/Wnt5a/Bmp7 |
| GO:0001503 | GO:0001503 | ossification | 260 | -0.4163773 | -1.689129 | 0.0000062 | 0.0010573 | 0.0009490 | 1813 | tags=23%, list=14%, signal=21% | Sgms2/Bmpr1b/Bmpr2/Calca/Pth1r/Tmem64/Tob1/Cited1/Rhoa/Id3/Zmpste24/H3f3b/Csgalnact1/Smoc1/Bpnt2/Bmpr1a/Tgfbr3/Sbds/Id2/Gpc3/Twsg1/Gsk3b/Tapt1/Atraid/Clic1/Fbxo5/Trp53inp2/Map3k7/Ccn1/Fbn2/Sort1/Bambi/Col13a1/Pkdcc/Intu/Ptger4/Fzd1/Jag1/Egr2/Acvr1/Bmp2/Pbx1/Klf10/Asf1a/Msx2/Mesd/Glis1/Pias2/Ctnnbip1/Alox15/Igsf10/Epha2/Ifitm1/Smad6/Ifi204/Cer1/Wnt3/Smad1/Wnt5a/Id1/Bmp7 |
| GO:0009880 | GO:0009880 | embryonic pattern specification | 53 | -0.6207465 | -2.038436 | 0.0000077 | 0.0012309 | 0.0011048 | 988 | tags=26%, list=8%, signal=24% | Tmed2/Meis3/Foxa2/Dll1/Frat1/Lhx1/Smad6/Meis2/Mesp1/Tdgf1/Efnb1/Wnt5a/Mesp2/Bmp7 |
| GO:0009410 | GO:0009410 | response to xenobiotic stimulus | 159 | -0.4662284 | -1.805222 | 0.0000082 | 0.0012770 | 0.0011461 | 1755 | tags=26%, list=14%, signal=23% | Blmh/Gstm7/Rhoa/Ncoa1/Mapk9/Abcb1b/Ube2b/Cyp26a1/Rasa1/Rap2a/Hnf4a/Pde3a/Ywhaz/Xbp1/Nudt15/Cd38/Rbm22/Tgfbr2/Gstm1/Ncam1/Cyp2s1/Gata4/As3mt/Rap1a/Fancb/Fzd1/N6amt1/Atg5/Rnf149/Tigar/Tent4a/Crot/Kdr/Trpa1/Gstm5/Hmga2/Rap1b/Jun/Smad1/Gata6/Fos |
| GO:0071363 | GO:0071363 | cellular response to growth factor stimulus | 447 | -0.3648536 | -1.563916 | 0.0000095 | 0.0014043 | 0.0012604 | 1895 | tags=20%, list=15%, signal=18% | Bmper/Fgfr1/Cd63/Lats2/Bmpr1b/Bmpr2/Pbld1/Calca/Cited2/Tob1/Zyx/Cited1/Lgmn/Wasf1/Ppm1a/Strap/Dusp22/Slc39a5/Pdcd6/Ndn/Tspan12/Bmpr1a/Ror2/Tgfbr3/Fgfbp1/Gpc3/Hspa5/Twsg1/Gsk3b/Pelo/Crb2/Hes1/Rasa1/Uri1/Slit2/Xbp1/Map3k7/Fgf17/Ramp2/Pik3ca/Ccn1/Adgra2/Tgfbr2/Fzd4/Fbn2/Dstyk/Ripk1/Emilin1/Sort1/Bambi/Gata4/Pde8a/Nrep/Rap1a/Fgf3/Hhex/Fzd1/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Kdr/Arpc2/Msx2/Dll1/Egr1/Zfp703/Nptn/Apln/Spred1/Sh3glb1/Lefty2/Smad6/Pdgfra/Jun/Fst/Tdgf1/Cer1/Msx1/Smad1/Zeb2/Etv2/Wnt5a/Klf4/Id1/Gata6/Bmp7/Fos |
| GO:0030509 | GO:0030509 | BMP signaling pathway | 113 | -0.5021097 | -1.848837 | 0.0000099 | 0.0014140 | 0.0012691 | 1973 | tags=31%, list=15%, signal=26% | Neo1/Bmper/Bmpr1b/Bmpr2/Tob1/Ppm1a/Slc39a5/Bmpr1a/Ror2/Tgfbr3/Gpc3/Twsg1/Pelo/Crb2/Hes1/Ccn1/Bambi/Gata4/Fzd1/Acvr1/Bmp2/Kdr/Msx2/Egr1/Lefty2/Smad6/Fst/Cer1/Msx1/Smad1/Etv2/Wnt5a/Id1/Gata6/Bmp7 |
| GO:0048762 | GO:0048762 | mesenchymal cell differentiation | 171 | -0.4645532 | -1.813914 | 0.0000108 | 0.0015062 | 0.0013518 | 1789 | tags=28%, list=14%, signal=24% | Glipr2/Rock1/Cdh2/Sdhaf2/Cited2/Phldb2/Clasp2/Pdcd6/Bmpr1a/Tgfbr3/Gsk3b/Cyp26a1/Crb2/Hes1/Tgfbr2/Adipor1/Hpn/Rock2/Efna1/Bambi/Hdac2/Mcrip1/Pofut2/Ezh2/Jag1/Sdcbp/Foxa2/Acvr1/Bmp2/Foxa1/Cdc42/Msx2/Zfp703/Wnt2/Gsc/Spred1/Fn1/Hmga2/Eomes/Ret/Snai1/Msx1/Efnb1/Frzb/Zeb2/Cyp26c1/Wnt5a/Bmp7 |
| GO:0043408 | GO:0043408 | regulation of MAPK cascade | 456 | -0.3628302 | -1.555205 | 0.0000180 | 0.0024456 | 0.0021950 | 2381 | tags=24%, list=19%, signal=20% | Atp6ap2/Fbln1/Avpi1/Nrk/Stk40/Flt1/Prdx1/Prkca/Met/Sash1/Slc9a3r1/Igfbp3/Erbb2/Klb/Unc5cl/Cib1/Tpd52l1/Pak1/Map2k2/Map2k4/Traf3/Bmper/Fgfr1/Ryk/L1cam/Ranbp9/Glipr2/Rock1/Abca7/Cdh2/Hmgb1/Pdgfa/Dok4/Dusp22/Mapk9/Psmd10/Mydgf/Fzd10/Ror2/Dusp10/Gsk3b/Sorbs3/Traf4/Rap2a/Cnksr3/Ywhaz/Xbp1/Map3k7/Tpbg/Sh2b3/Ccn1/Fzd4/Epha4/Atf3/Tnfrsf19/Apoe/Rock2/Rell1/Dstyk/Ripk1/Emilin1/Emc10/Efna1/Gata4/Ptpn2/Pde8a/Zfp622/Rap1a/Ezh2/Pdcd10/Cx3cl1/Thbs1/Ceacam1/Rnf149/Bmp2/Fgg/Kdr/Cdc42/Mfhas1/Fga/Apip/Fgb/Nptn/Dusp6/Dnaja1/Spred1/Dact1/Igfbp4/Alox15/Fn1/Pbk/E130311K13Rik/Epha2/Rap1b/Pdgfra/Jun/Ret/Cd24a/Hipk3/Tdgf1/Adra2b/Peli2/Dusp5/Dusp1/Zeb2/Wnt5a/Klf4/Aida/Id1/Bmp7 |
| GO:0061053 | GO:0061053 | somite development | 65 | -0.5797452 | -1.989549 | 0.0000184 | 0.0024461 | 0.0021954 | 1394 | tags=31%, list=11%, signal=28% | Bmpr1a/Ror2/Six4/Crb2/Xrcc2/Tmed2/Plxna2/Pcdh8/Foxa2/Dll1/Lfng/Lhx1/Ifitm1/Mesp1/Dll3/T/Frzb/Zeb2/Wnt5a/Mesp2 |
| GO:0001756 | GO:0001756 | somitogenesis | 53 | -0.6012286 | -1.974342 | 0.0000236 | 0.0029869 | 0.0026808 | 1394 | tags=34%, list=11%, signal=30% | Bmpr1a/Ror2/Crb2/Xrcc2/Tmed2/Plxna2/Pcdh8/Foxa2/Dll1/Lfng/Lhx1/Ifitm1/Mesp1/Dll3/T/Zeb2/Wnt5a/Mesp2 |
| GO:0090287 | GO:0090287 | regulation of cellular response to growth factor stimulus | 208 | -0.4285003 | -1.718446 | 0.0000253 | 0.0031228 | 0.0028028 | 1895 | tags=26%, list=15%, signal=23% | Bmper/Fgfr1/Cd63/Lats2/Bmpr2/Pbld1/Cited2/Tob1/Wasf1/Ppm1a/Strap/Pdcd6/Tspan12/Tgfbr3/Fgfbp1/Gpc3/Hspa5/Twsg1/Pelo/Crb2/Hes1/Slit2/Xbp1/Ccn1/Adgra2/Fzd4/Fbn2/Dstyk/Emilin1/Bambi/Gata4/Nrep/Hhex/Fzd1/Sdcbp/Thbs1/Bmp2/Snx6/Kdr/Msx2/Dll1/Zfp703/Nptn/Apln/Spred1/Sh3glb1/Smad6/Fst/Tdgf1/Cer1/Msx1/Zeb2/Wnt5a/Gata6 |
| GO:0034114 | GO:0034114 | regulation of heterotypic cell-cell adhesion | 18 | -0.8129693 | -2.079981 | 0.0000359 | 0.0041464 | 0.0037214 | 1166 | tags=44%, list=9%, signal=40% | Apoa1/Myadm/Fgg/Fga/Fgb/Alox15/Klf4/Bmp7 |
| GO:0045165 | GO:0045165 | cell fate commitment | 147 | -0.4546693 | -1.744012 | 0.0000517 | 0.0057139 | 0.0051283 | 701 | tags=18%, list=5%, signal=18% | Cdc73/Gata4/Tenm4/Lmo4/Tm2d3/Foxa2/Acvr1/Bmp2/Foxa1/Kdr/Zfp521/Cdc42/Dll1/Wnt2/Glis1/Gsc/Eomes/Mesp1/Gas1/Dll3/T/Wnt5b/Wnt3/Smad1/Etv2/Wnt5a/Gata6 |
| GO:0061311 | GO:0061311 | cell surface receptor signaling pathway involved in heart development | 21 | -0.7730332 | -2.058955 | 0.0000546 | 0.0059127 | 0.0053068 | 509 | tags=43%, list=4%, signal=41% | Jag1/Acvr1/Bmp2/Msx2/Dll1/Mesp1/Snai1/Msx1/Wnt5a |
| GO:0071772 | GO:0071772 | response to BMP | 116 | -0.4964396 | -1.845316 | 0.0000610 | 0.0062280 | 0.0055898 | 1973 | tags=30%, list=15%, signal=26% | Neo1/Bmper/Bmpr1b/Bmpr2/Tob1/Ppm1a/Slc39a5/Bmpr1a/Ror2/Tgfbr3/Gpc3/Twsg1/Pelo/Crb2/Hes1/Ccn1/Bambi/Gata4/Fzd1/Acvr1/Bmp2/Kdr/Msx2/Egr1/Lefty2/Smad6/Fst/Cer1/Msx1/Smad1/Etv2/Wnt5a/Id1/Gata6/Bmp7 |
| GO:0071773 | GO:0071773 | cellular response to BMP stimulus | 116 | -0.4964396 | -1.845316 | 0.0000610 | 0.0062280 | 0.0055898 | 1973 | tags=30%, list=15%, signal=26% | Neo1/Bmper/Bmpr1b/Bmpr2/Tob1/Ppm1a/Slc39a5/Bmpr1a/Ror2/Tgfbr3/Gpc3/Twsg1/Pelo/Crb2/Hes1/Ccn1/Bambi/Gata4/Fzd1/Acvr1/Bmp2/Kdr/Msx2/Egr1/Lefty2/Smad6/Fst/Cer1/Msx1/Smad1/Etv2/Wnt5a/Id1/Gata6/Bmp7 |
| GO:0060284 | GO:0060284 | regulation of cell development | 410 | -0.3575532 | -1.521781 | 0.0000644 | 0.0064038 | 0.0057475 | 1418 | tags=18%, list=11%, signal=17% | Proc/S100a10/Marcks/Bmpr1a/Ywhah/Dusp10/Id2/Gsk3b/Hes1/Qk/Cdk5/Xrcc2/Slit2/Ap1ar/Rreb1/Pde3a/Dnajb11/Apoa1/Ppp1cc/Fmr1/Reln/Ninj1/Adgra2/Man2a1/Myadm/Rnf10/Epha4/Apoe/Cdkl5/Aurka/Rock2/Trim32/Plxna2/Ifrd1/Chd7/Tenm4/Trim46/Trf/Hdac2/Ezh2/Cx3cl1/Egr2/Nin/Ntn1/Bmp2/Efnb3/Calr/Tnfrsf1b/Bad/Kdr/Rac1/Cdc42/Arpc2/Dll1/Nptn/Wnt2/Pias2/Picalm/Sh3glb1/Fn1/Hmga2/Tmem98/Ret/Tnfrsf1a/Cd24a/Rab11a/Dll3/Wnt3/Frzb/Zeb2/Prtg/Wnt5a/Tiam2/Id1/Bmp7 |
| GO:0002009 | GO:0002009 | morphogenesis of an epithelium | 418 | -0.3563960 | -1.519364 | 0.0000652 | 0.0064038 | 0.0057475 | 1659 | tags=21%, list=13%, signal=19% | Cited2/Prickle1/Cited1/Rhoa/Phldb2/Clasp2/Pdgfa/Tsc1/Tmem67/Prox1/Slc12a2/Gorab/Ctsh/Ror2/Six4/Rhob/Gpc3/Actg1/Hes1/Exoc5/Pkd1/Efnb2/Chuk/Slit2/Rreb1/Socs3/Wnk4/Map3k7/Cfc1/Sec24b/Fzd2/Ccn1/Enah/Ctsl/Tgfbr2/Tmed2/Epha4/Rock2/Rala/Pcdh8/Zdhhc7/Gata4/Ctsz/Dlc1/Intu/Nkd1/Lmo4/Fgf3/Coq7/Hhex/Fzd1/Pdcd10/Jag1/Foxa2/Acvr1/Ntn1/Bmp2/Actb/Foxa1/Bcl10/Grsf1/Pbx1/Kdr/Rac1/Cdc42/Msx2/Dll1/Wnt2/Znrf3/Ctnnbip1/Dact1/Lhx1/Ipmk/Aplnr/Epha2/Hmga2/Pdgfra/Ret/Lgr5/Mesp1/Snai1/Fst/T/Frzb/Zeb2/Wnt5a/Klf4/Bmp7 |
| GO:0001649 | GO:0001649 | osteoblast differentiation | 141 | -0.4587715 | -1.748988 | 0.0000848 | 0.0079641 | 0.0071480 | 2335 | tags=34%, list=18%, signal=28% | Chrd/Sh3pxd2b/Igfbp3/Dlk1/H3f3a/Zfp932/Hey1/Fgfr1/Bmpr1b/Bmpr2/Pth1r/Tmem64/Tob1/Cited1/Id3/H3f3b/Smoc1/Bmpr1a/Tgfbr3/Id2/Twsg1/Gsk3b/Atraid/Clic1/Fbxo5/Trp53inp2/Map3k7/Ccn1/Fbn2/Bambi/Ptger4/Fzd1/Jag1/Acvr1/Bmp2/Asf1a/Msx2/Glis1/Pias2/Ctnnbip1/Epha2/Ifitm1/Smad6/Ifi204/Wnt3/Smad1/Id1/Bmp7 |
| GO:0090092 | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 173 | -0.4394713 | -1.717546 | 0.0000855 | 0.0079641 | 0.0071480 | 1895 | tags=25%, list=15%, signal=22% | Bmper/Lats2/Bmpr2/Pbld1/Cited2/Tob1/Ppm1a/Strap/Bmpr1a/Tgfbr3/Gpc3/Hspa5/Twsg1/Pelo/Crb2/Hes1/Xbp1/Ccn1/Inhbc/Fbn2/Emilin1/Bambi/Gata4/Nrep/Fzd1/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Kdr/Msx2/Zfp703/Spred1/Lefty2/Smad6/Fst/Tdgf1/Cer1/Msx1/Zeb2/Wnt5a/Gata6/Bmp7 |
| GO:0050673 | GO:0050673 | epithelial cell proliferation | 277 | -0.3917710 | -1.603094 | 0.0000925 | 0.0084225 | 0.0075594 | 2307 | tags=29%, list=18%, signal=24% | Flt1/Prkca/Stat5a/Igfbp3/Erbb2/Thap1/Dlk1/Aqp11/Ift52/Hey1/BC004004/Map2k2/Bmper/Fgfr1/Brca2/Bmpr2/Calca/Hmgb1/Stxbp4/Itpr1/B2m/Prox1/Npm1/Mydgf/Pdcd6/Birc5/Bmpr1a/Six4/Tgfbr3/Dusp10/Apela/Id2/Fgfbp1/Gpc3/Hes1/Efnb2/Chuk/Rreb1/Apoa1/Xbp1/Pdcl3/Pygo2/Ctsl/Apoe/Hpn/Pold4/Cdc73/Emc10/Adora2b/Irf6/Intu/Rida/Ppp1r16b/Pdcd10/Thbs1/Ceacam1/Bmp2/Bad/Pex2/Kdr/Cdc42/Mcc/Zfp703/Wnt2/Apln/Tcf19/Aimp1/Igfbp4/Aplnr/Ccnd2/Epha2/Hmga2/Jun/Lgr5/Fst/Gas1/Cyba/Wnt5a/Id1 |
| GO:0042445 | GO:0042445 | hormone metabolic process | 93 | -0.5138568 | -1.848536 | 0.0000936 | 0.0084225 | 0.0075594 | 2575 | tags=37%, list=20%, signal=29% | Nfkb1/Arnt/Atp6ap2/Slc16a10/Scg5/Rdh10/Hsd17b2/Fdx1/Bmpr1b/Scp2/Zmpste24/Afp/Ctsb/Cpe/Crabp1/Pcsk5/Cyp26a1/Cacna1a/Ttr/Reln/Ctsl/Gal/Hpn/Cyp2s1/Por/Bmp2/Foxa1/Egr1/Rdh11/Pdgfra/Rbp4/Tiparp/Rbp1/Cyp26c1 |
| GO:0035051 | GO:0035051 | cardiocyte differentiation | 116 | -0.4891720 | -1.818302 | 0.0001064 | 0.0092597 | 0.0083108 | 1659 | tags=35%, list=13%, signal=31% | Srf/Acadm/Trip10/Tbx3/Hnrnpu/Folr1/Met/Sox17/Col14a1/Pak1/Map2k4/Tomm70a/Cited2/Prickle1/Zmpste24/Tsc1/Prox1/Bmpr1a/Tgfbr3/Slc25a4/Gsk3b/Hes1/Efnb2/Gata4/Cacybp/Tenm4/Hdac2/Jag1/Atg5/Acvr1/Bmp2/Cdc42/Dll1/Eomes/Smad6/Pdgfra/Mesp1/Tdgf1/T/Gata6/Bmp7 |
| GO:0051205 | GO:0051205 | protein insertion into membrane | 46 | -0.6126479 | -1.955240 | 0.0001102 | 0.0094363 | 0.0084693 | 1223 | tags=24%, list=10%, signal=22% | Mmgt1/Emc10/Emc6/Maip1/Mmgt2/Tomm22/Timm29/Emc7/Tram1/Sh3glb1/Emc2 |
| GO:0043433 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 122 | -0.4688972 | -1.751045 | 0.0001399 | 0.0117842 | 0.0105766 | 1917 | tags=29%, list=15%, signal=25% | Traf3/Glis2/Ddit3/Prmt2/Chp1/Pex14/Commd1/Id3/Prox1/Psmd10/Ndn/Id2/Hes1/Pkd1/Chuk/Tut4/Hnf4a/Creb3/Cebpg/Sigirr/Hdac2/Ezh2/Foxa2/Pbx1/Sumo1/Msx2/Pias2/Foxj1/Ctnnbip1/Commd6/Sri/Eomes/T/Klf4/Id1 |
| GO:0048645 | GO:0048645 | animal organ formation | 46 | -0.6056315 | -1.932848 | 0.0001473 | 0.0122170 | 0.0109650 | 2147 | tags=33%, list=17%, signal=27% | Rdh10/Map2k2/Fgfr1/Cited2/Bmpr1a/Hes1/Tgfbr2/Fgf3/Hhex/Bmp2/Wnt2/Mesp1/Wnt5a/Gata6/Bmp7 |
| GO:0090277 | GO:0090277 | positive regulation of peptide hormone secretion | 71 | -0.5448546 | -1.882893 | 0.0001529 | 0.0123890 | 0.0111194 | 1028 | tags=27%, list=8%, signal=25% | Cd38/Oga/Rab8b/Serp1/Ptger4/Mcu/Bad/Fgg/Osbp/Rac1/Fga/Fgb/Apln/Aimp1/Sri/Trpa1/Rbp4/C2cd2l/Mpc2 |
| GO:0010718 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 36 | -0.6258435 | -1.891024 | 0.0001541 | 0.0123890 | 0.0111194 | 1296 | tags=33%, list=10%, signal=30% | Crb2/Tgfbr2/Bambi/Hdac2/Ezh2/Jag1/Sdcbp/Acvr1/Bmp2/Zfp703/Snai1/Bmp7 |
| GO:0002793 | GO:0002793 | positive regulation of peptide secretion | 72 | -0.5416862 | -1.879851 | 0.0001586 | 0.0125656 | 0.0112779 | 1028 | tags=26%, list=8%, signal=24% | Cd38/Oga/Rab8b/Serp1/Ptger4/Mcu/Bad/Fgg/Osbp/Rac1/Fga/Fgb/Apln/Aimp1/Sri/Trpa1/Rbp4/C2cd2l/Mpc2 |
| GO:0006457 | GO:0006457 | protein folding | 132 | -0.4622487 | -1.735202 | 0.0001762 | 0.0137497 | 0.0123407 | 2360 | tags=30%, list=18%, signal=24% | Ptges3/Dnajb3/Chordc1/Ahsa2/Sdf2/Bag5/Grpel1/Hsp90b1/Vbp1/Pex19/Chchd4/B2m/Dnaja2/Dffa/Pdia5/Ppil3/Cct2/Hspa5/St13/Dnajb11/Tbca/Pdcl3/Cct3/Tbcc/Pofut2/Hspa14/Calr/Erp44/Pdia3/Sdf2l1/Mesd/Dnajb2/Nudcd2/Dnaja1/Sh3glb1/Entpd5/Ppic/Selenof/Ppib |
| GO:0061061 | GO:0061061 | muscle structure development | 432 | -0.3422029 | -1.460869 | 0.0002015 | 0.0150630 | 0.0135194 | 2100 | tags=24%, list=16%, signal=21% | Col14a1/Cd9/Wdr1/Cdk9/Pak1/Hey1/Cd164/Foxn2/Neo1/Foxo4/Map2k4/Cops2/Stra6/Tomm70a/Mtm1/Sfmbt1/Ddit3/Bmpr2/Efemp2/Cdh2/Glmn/Cited2/Prickle1/Rhoa/Krt8/Med28/Hlf/Id3/Zmpste24/Tsc1/Cfl2/Prox1/H3f3b/Camk1/H1f5/Bmpr1a/Six4/Tgfbr3/Slc25a4/Id2/Srpk3/Actg1/Gsk3b/Hes1/Qk/Cdk5/Tpm1/Efnb2/Chuk/Plekho1/Med20/Xbp1/Fzd2/Ninj1/Ramp2/Mettl8/Atf3/Trim32/Plpp7/Sin3b/Tmsb4x/Ifrd1/Sort1/Serp1/Chd7/Gata4/Heg1/Cacybp/Psma6/Hdac2/Pdlim4/Frg1/Fgf3/Pmp22/Ezh2/Fzd1/Egr2/Dtnbp1/Atg5/Ptgfrn/Acvr1/Bmp2/Pkp2/Asf1a/Ptcd2/Dll1/Egr1/Wnt2/Gsc/Aplnr/Cth/Eomes/Smad6/Pdgfra/Mesp1/Tdgf1/Rcan1/T/Msx1/Smad1/Wnt5a/Tsc22d3/Gata6/Fos |
| GO:0010463 | GO:0010463 | mesenchymal cell proliferation | 38 | -0.6285071 | -1.905843 | 0.0002320 | 0.0166361 | 0.0149313 | 1878 | tags=37%, list=15%, signal=32% | Fgfr1/Hmgb1/Pdgfa/Bmpr1a/Gpc3/Tgfbr2/Bmp2/Kdr/Wnt2/Ctnnbip1/Gas1/Msx1/Wnt5a/Bmp7 |
| GO:0030901 | GO:0030901 | midbrain development | 33 | -0.6493921 | -1.925022 | 0.0002403 | 0.0170057 | 0.0152631 | 1878 | tags=33%, list=15%, signal=29% | Fgfr1/Ryk/Hes1/Uchl5/Rac1/Wnt2/Wls/Msx1/Wnt3/Smad1/Wnt5a |
| GO:0031018 | GO:0031018 | endocrine pancreas development | 29 | -0.6679604 | -1.936980 | 0.0002482 | 0.0171556 | 0.0153976 | 1713 | tags=28%, list=13%, signal=24% | Cdh2/Hes1/Hnf4a/Foxa2/Bad/Dll1/Wnt5a/Gata6 |
| GO:0071514 | GO:0071514 | genetic imprinting | 31 | 0.6588725 | 2.005713 | 0.0002578 | 0.0171556 | 0.0153976 | 441 | tags=23%, list=3%, signal=22% | Tet1/Dnmt3a/Dnmt3l/Meg3/Gnasas1/Dnmt3b/Arid4a |
| GO:0001656 | GO:0001656 | metanephros development | 52 | -0.5848577 | -1.914118 | 0.0002583 | 0.0171556 | 0.0153976 | 2188 | tags=35%, list=17%, signal=29% | Sox17/Fbn1/Rdh10/Sall1/Akr1b3/Cited1/Pdgfa/Id3/Six4/Id2/Gpc3/Hes1/Slit2/Egr1/Lhx1/Pdgfra/Ret/Bmp7 |
| GO:0006720 | GO:0006720 | isoprenoid metabolic process | 49 | -0.5939421 | -1.918513 | 0.0002601 | 0.0171556 | 0.0153976 | 1756 | tags=37%, list=14%, signal=32% | Idi1/Akr1b3/Dpagt1/Amacr/Crabp1/Cyp26a1/Coq2/Ttr/Pdss1/Cyp2s1/Bco1/Srd5a3/Rdh11/Rdh13/Rbp4/Phyh/Rbp1/Cyp26c1 |
| GO:0050679 | GO:0050679 | positive regulation of epithelial cell proliferation | 129 | -0.4461705 | -1.677622 | 0.0002633 | 0.0171556 | 0.0153976 | 1878 | tags=26%, list=15%, signal=23% | Fgfr1/Bmpr2/Hmgb1/Stxbp4/Itpr1/Prox1/Mydgf/Pdcd6/Bmpr1a/Apela/Fgfbp1/Rreb1/Xbp1/Pdcl3/Hpn/Pold4/Emc10/Adora2b/Ppp1r16b/Bmp2/Bad/Kdr/Cdc42/Zfp703/Wnt2/Apln/Aplnr/Ccnd2/Hmga2/Jun/Gas1/Cyba/Wnt5a/Id1 |
| GO:0034103 | GO:0034103 | regulation of tissue remodeling | 46 | -0.5939885 | -1.895690 | 0.0002671 | 0.0171556 | 0.0153976 | 2780 | tags=41%, list=22%, signal=32% | Fgfr3/Ppargc1b/Suco/Prkca/Tfrc/Dlk1/Rock1/Calca/Tmem64/Cd38/Rock2/Gata4/Trf/Itgav/Ptger4/Ceacam1/Klf6/Bcr/Cd24a |
| GO:0043046 | GO:0043046 | DNA methylation involved in gamete generation | 13 | 0.8097042 | 1.997213 | 0.0002683 | 0.0171556 | 0.0153976 | 1234 | tags=46%, list=10%, signal=42% | Dnmt3a/Dnmt3l/Tdrd12/Pld6/Fkbp6/Mael |
| GO:1902532 | GO:1902532 | negative regulation of intracellular signal transduction | 408 | -0.3443783 | -1.466922 | 0.0002968 | 0.0184258 | 0.0165376 | 1852 | tags=21%, list=14%, signal=18% | Ranbp9/Nploc4/Mtm1/Ddit3/Trim67/Abca7/Tank/Rffl/Stmn3/Chp1/Rhoa/Itpr1/Cd2ap/Ppm1a/Tsc1/Gpatch3/Mapkap1/Psmd10/Ube2b/Pdcd6/Dusp10/Mcl1/Rnf34/Gsk3b/Uri1/Cnksr3/Slit2/Pde3a/Ppp1r10/Xbp1/Cul3/Sh2b3/Vdac2/Triap1/Rabgef1/Creb3/Myadm/Atf3/Apoe/Adipor1/Aurka/Trim32/Ripk1/Emilin1/Efna1/Selenos/Bcl2l1/Tbc1d7/Heg1/Ptpn2/Dlc1/Hdac2/Wtip/Trim59/Lmbrd1/Cdkn2d/Thbs1/Ceacam1/Rnf149/Bmp2/Dyrk2/Dusp6/Dnaja1/Spred1/Dact1/Stambp/Tspan6/Sh3glb1/Aplnr/Kptn/Pbk/E130311K13Rik/Rasa4/Epha2/Kctd13/Snai1/Hipk3/Rcan1/Txndc12/Dusp5/Dusp1/Cyrib/Klf4/Aida/Bmp7 |
| GO:0043414 | GO:0043414 | macromolecule methylation | 267 | 0.3649987 | 1.547237 | 0.0003021 | 0.0184258 | 0.0165376 | 2005 | tags=23%, list=16%, signal=20% | Tet1/Dnmt3a/Grhl2/Dnmt3l/Meg3/Tdrd12/Gnasas1/Zc3h13/Mettl15/Bend3/Rab3d/Nelfe/Dnmt3b/Dppa2/Kmt2a/Kdm3a/Tet3/Wdr5b/Arid4a/Setd2/Kdm4a/Ilf3/Baz2a/Kmt2d/Atf7ip/Pld6/Dalrd3/Trmt12/Rif1/Setd7/Ftx/H1f4/Kdm4c/Fkbp6/Parp1/Ehmt1/Supt6/Bcor/Setd4/Mael/Mettl22/Rtf1/Nsd3/Ftsj3/Atrx/Setd5/Mtr/Nsd1/Zfp110/Chtop/L3mbtl2/Jarid2/Iws1/Zfp335/Hemk1/Brca1/Paxbp1/Pcif1/Mettl14/Mto1/Dnmt1 |
| GO:0008285 | GO:0008285 | negative regulation of cell population proliferation | 461 | -0.3320917 | -1.424548 | 0.0003109 | 0.0187475 | 0.0168264 | 2307 | tags=23%, list=18%, signal=20% | Flt1/Prkca/Cops8/Slc9a3r1/Igfbp3/Erbb2/Rerg/Peli1/Smyd2/Pawr/Dlk1/Aqp11/Cib1/Cd9/Ift52/Pak1/Strn/Sdc4/Foxo4/Pds5b/Brca2/Eef1e1/Bmpr2/Efemp2/Pth1r/Glmn/Nudt6/Cited2/Tob1/Rhoa/B2m/Tsc1/Tfap4/Prox1/Npm1/Ndn/Ror2/Tgfbr3/Rnf139/Dusp10/Gpc3/Twsg1/Atraid/Hes1/Tpm1/Efnb2/Hnf4a/Slit2/Tsg101/Tpbg/Sh2b3/Ctsl/Tgfbr2/Rnf10/Ppp1r15a/Gal/Apoe/Hpn/Trim32/Ripk1/Cdc73/Smarcb1/Adora2b/Irf6/Ptpn2/Dlc1/Hdac2/Tes/B4galt7/Intu/Pmp22/Rida/Pdcd10/Cdkn2d/Thbs1/Ceacam1/Bmp2/Pex2/H19/Msx2/Dll1/Mcc/Dnajb2/Fth1/Apln/Foxj1/Ctnnbip1/Aimp1/Tbrg1/P3h2/Med31/Cth/Ifitm1/Smad6/Jun/Rbp4/Cd24a/Gas1/Cer1/Msx1/Smad1/Frzb/Dusp1/Fxyd2/Wnt5a/Klf4/Gata6/Bmp7 |
| GO:0070371 | GO:0070371 | ERK1 and ERK2 cascade | 206 | -0.3902005 | -1.563145 | 0.0003520 | 0.0209915 | 0.0188403 | 1204 | tags=23%, list=9%, signal=21% | Map2k2/Bmper/L1cam/Ranbp9/Glipr2/Abca7/Hmgb1/Pdgfa/Ctsh/Dusp10/Cnksr3/Ywhaz/Xbp1/Tpbg/Ccn1/Atf3/Apoe/Dstyk/Emilin1/Gata4/Ptpn2/Pde8a/Trf/Itgav/Ptger4/Rap1a/Cx3cl1/Ceacam1/Bmp2/Fgg/Kdr/Mfhas1/Fga/Apip/Fgb/Nptn/Dusp6/Spred1/Alox15/Fn1/E130311K13Rik/Epha2/Rap1b/Pdgfra/Jun/Dusp1/Klf4 |
| GO:0010817 | GO:0010817 | regulation of hormone levels | 283 | -0.3727138 | -1.533546 | 0.0003763 | 0.0221907 | 0.0199166 | 2309 | tags=27%, list=18%, signal=23% | Ptpmt1/Vamp8/Igfbp3/Slc16a10/Snx19/Scg5/Rdh10/Hsd17b2/Jagn1/Cdk16/Slc9b2/Fdx1/Slc7a8/Fgfr1/Bmpr1b/Sirt4/Stxbp4/Scp2/Snx4/Zmpste24/Cyb5r4/Afp/Rab1a/Birc5/Ctsb/Cpe/Crabp1/Pcsk5/Cyp26a1/Cacna1a/Pomc/Hnf4a/Pde1c/Ttr/Ywhaz/Reln/Cd38/Ctsl/Fzd4/Hmgn3/Gal/Ndufaf2/Hpn/Oga/Rab8b/Serp1/Cyp2s1/Chd7/Ptger4/Rab11fip3/Por/Foxa2/Bmp2/Foxa1/Mcu/Bad/Fgg/Osbp/Rac1/Fga/Slc16a1/Fgb/Egr1/Rdh11/Apln/Aimp1/Sri/Trpa1/Hmga2/Pdgfra/Rbp4/C2cd2l/Tiparp/Rbp1/Mpc2/Cyp26c1 |
| GO:0006888 | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 106 | -0.4653459 | -1.709687 | 0.0003971 | 0.0227816 | 0.0204470 | 1525 | tags=25%, list=12%, signal=23% | Ergic2/Cnih4/Pdcd6/Vapb/Rab1a/Rnf139/Sec22b/Kdelr1/Bcap29/Sar1b/Cul3/Sec24b/Vti1a/Tmed2/Ykt6/Trappc4/Trappc6b/Trappc8/Bet1/Tmed7/0610009B22Rik/Kdelr3/Vapa/Sar1a/Yif1a/Yipf4/Gas1 |
| GO:0045048 | GO:0045048 | protein insertion into ER membrane | 23 | -0.7132367 | -1.950267 | 0.0004026 | 0.0227816 | 0.0204470 | 1223 | tags=30%, list=10%, signal=28% | Mmgt1/Emc10/Emc6/Mmgt2/Emc7/Tram1/Emc2 |
| GO:0007179 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 134 | -0.4406429 | -1.664335 | 0.0004035 | 0.0227816 | 0.0204470 | 1840 | tags=24%, list=14%, signal=21% | Lats2/Bmpr1b/Pbld1/Cited2/Zyx/Cited1/Ppm1a/Strap/Dusp22/Tgfbr3/Hspa5/Twsg1/Xbp1/Map3k7/Tgfbr2/Fbn2/Emilin1/Bambi/Nrep/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Zfp703/Spred1/Smad6/Jun/Tdgf1/Smad1/Zeb2/Fos |
| GO:0048863 | GO:0048863 | stem cell differentiation | 160 | -0.4231474 | -1.644007 | 0.0004202 | 0.0234520 | 0.0210487 | 541 | tags=14%, list=4%, signal=13% | Hhex/Fzd1/Jag1/Acvr1/Foxa1/Cdc42/Msx2/Gsc/Fn1/Ociad1/Eomes/Pdgfra/Ret/T/Msx1/Efnb1/Wnt3/Frzb/Zeb2/Cyp26c1/Gata6/Bmp7 |
| GO:0002763 | GO:0002763 | positive regulation of myeloid leukocyte differentiation | 33 | -0.6365849 | -1.887057 | 0.0004242 | 0.0234520 | 0.0210487 | 2287 | tags=48%, list=18%, signal=40% | Prkca/Stat5a/Dlk1/Slc9b2/Calca/Tmem64/Fes/Ror2/Id2/Gsk3b/Ninj1/Ripk1/Klf10/Ctnnbip1/Jun/Fos |
| GO:0045667 | GO:0045667 | regulation of osteoblast differentiation | 99 | -0.4827090 | -1.755548 | 0.0004506 | 0.0246513 | 0.0221251 | 2154 | tags=34%, list=17%, signal=29% | Dlk1/Zfp932/Hey1/Fgfr1/Bmpr1b/Bmpr2/Tmem64/Tob1/Cited1/Id3/Smoc1/Bmpr1a/Id2/Twsg1/Gsk3b/Atraid/Clic1/Fbxo5/Ccn1/Fbn2/Bambi/Ptger4/Jag1/Acvr1/Bmp2/Msx2/Pias2/Ctnnbip1/Ifitm1/Smad6/Ifi204/Smad1/Id1/Bmp7 |
| GO:0051347 | GO:0051347 | positive regulation of transferase activity | 367 | -0.3437975 | -1.449979 | 0.0004755 | 0.0256949 | 0.0230618 | 2362 | tags=26%, list=18%, signal=22% | Stradb/Ptges3/Rps2/Pibf1/Flt1/Met/Cops8/Sash1/Erbb2/Fbn1/Pfkfb1/Cacul1/Cib1/Tpd52l1/Pak1/Osbpl8/Snx9/Sdc4/Map2k2/Map2k4/Dcun1d1/Fgfr1/Pih1d1/Ryk/Mmd/Calca/Rhoa/Pdgfa/Prox1/Npm1/Ppp1r3g/Ralb/Psmd10/Camk1/Fzd10/Zfp91/Marcks/Ror2/Dusp12/Cct2/Cdk5/Traf4/Pkd1/Rfc3/Hnf4a/Apoa1/Map3k7/Reln/Rfc4/Ccn1/Hnrnpd/Tgfbr2/Fzd4/Ube2l3/Epha4/Arrdc4/Dbi/Dstyk/Ripk1/Efna1/Nek7/Cab39/Zfp622/Lmo4/Rap1a/Malt1/Ezh2/Ccny/Pdcd10/Dcun1d5/Thbs1/Ceacam1/Bad/Tigar/Kdr/Dcun1d3/Rac1/Cdc42/Nbn/Egr1/Ube2n/Sh3glb1/Skp1/Ccnd2/Epha2/Hmga2/Strada/Pdgfra/Ret/Cd24a/Tdgf1/Adra2b/Zeb2/Wnt5a/Klf4 |
| GO:0033674 | GO:0033674 | positive regulation of kinase activity | 289 | -0.3692882 | -1.521034 | 0.0004812 | 0.0256949 | 0.0230618 | 2400 | tags=27%, list=19%, signal=22% | Ephb3/Stradb/Pibf1/Flt1/Met/Cops8/Sash1/Erbb2/Fbn1/Pfkfb1/Cacul1/Cib1/Tpd52l1/Pak1/Osbpl8/Snx9/Sdc4/Map2k2/Map2k4/Fgfr1/Pih1d1/Ryk/Mmd/Calca/Rhoa/Pdgfa/Prox1/Npm1/Ralb/Psmd10/Camk1/Fzd10/Zfp91/Marcks/Ror2/Dusp12/Cdk5/Traf4/Pkd1/Hnf4a/Map3k7/Reln/Ccn1/Tgfbr2/Fzd4/Epha4/Dstyk/Efna1/Cab39/Zfp622/Lmo4/Rap1a/Malt1/Ezh2/Ccny/Pdcd10/Thbs1/Ceacam1/Bad/Tigar/Kdr/Rac1/Cdc42/Nbn/Egr1/Sh3glb1/Ccnd2/Epha2/Hmga2/Strada/Pdgfra/Ret/Cd24a/Tdgf1/Adra2b/Zeb2/Wnt5a |
| GO:0051101 | GO:0051101 | regulation of DNA binding | 92 | -0.4691337 | -1.689348 | 0.0004882 | 0.0256949 | 0.0230618 | 759 | tags=25%, list=6%, signal=24% | Calm1/Hey1/Ddit3/Hmgb1/Zmpste24/Tfap4/Id2/Hes1/H1f0/Hdac2/Taf10/Sumo1/Msx2/Ctnnbip1/Sri/Hmga2/Jun/Hipk3/Ifi204/Msx1/Gtf2b/Klf4/Id1 |
| GO:0071901 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 79 | -0.4930092 | -1.736536 | 0.0004890 | 0.0256949 | 0.0230618 | 1561 | tags=22%, list=12%, signal=19% | Tfap4/Pkia/Hexim1/Dusp10/Gsk3b/Sh2b3/Apoe/Heg1/Hhex/Dtnbp1/Bmp2/Dnaja1/Pkig/Hipk3/Dusp1/Aida/Bmp7 |
| GO:0045766 | GO:0045766 | positive regulation of angiogenesis | 105 | -0.4559114 | -1.673206 | 0.0005145 | 0.0265085 | 0.0237920 | 1688 | tags=25%, list=13%, signal=22% | Hmgb1/S100a1/Mydgf/Pdcd6/Ctsh/Apela/Rhob/Xbp1/Ets1/Ninj1/Ramp2/Pdcl3/Tgfbr2/Emc10/Gata4/Cx3cl1/Thbs1/Kdr/Dll1/Aplnr/Hmga2/Tnfrsf1a/Smad1/Wnt5a/Klf4/Gata6 |
| GO:1904018 | GO:1904018 | positive regulation of vasculature development | 105 | -0.4559114 | -1.673206 | 0.0005145 | 0.0265085 | 0.0237920 | 1688 | tags=25%, list=13%, signal=22% | Hmgb1/S100a1/Mydgf/Pdcd6/Ctsh/Apela/Rhob/Xbp1/Ets1/Ninj1/Ramp2/Pdcl3/Tgfbr2/Emc10/Gata4/Cx3cl1/Thbs1/Kdr/Dll1/Aplnr/Hmga2/Tnfrsf1a/Smad1/Wnt5a/Klf4/Gata6 |
| GO:0032488 | GO:0032488 | Cdc42 protein signal transduction | 10 | -0.8505460 | -1.890174 | 0.0005430 | 0.0274466 | 0.0246340 | 1166 | tags=50%, list=9%, signal=46% | Apoa1/Apoe/Rhou/Ntn1/Cdc42 |
| GO:0034754 | GO:0034754 | cellular hormone metabolic process | 43 | -0.5918328 | -1.852471 | 0.0005830 | 0.0289134 | 0.0259504 | 2147 | tags=40%, list=17%, signal=33% | Rdh10/Hsd17b2/Bmpr1b/Scp2/Afp/Crabp1/Cyp26a1/Ttr/Cyp2s1/Bmp2/Egr1/Rdh11/Pdgfra/Rbp4/Tiparp/Rbp1/Cyp26c1 |
| GO:0046887 | GO:0046887 | positive regulation of hormone secretion | 90 | -0.4845610 | -1.737667 | 0.0006388 | 0.0311002 | 0.0279132 | 1028 | tags=22%, list=8%, signal=21% | Cd38/Gal/Oga/Rab8b/Serp1/Ptger4/Mcu/Bad/Fgg/Osbp/Rac1/Fga/Fgb/Apln/Aimp1/Sri/Trpa1/Rbp4/C2cd2l/Mpc2 |
| GO:2001214 | GO:2001214 | positive regulation of vasculogenesis | 10 | -0.8444125 | -1.876543 | 0.0006560 | 0.0314002 | 0.0281824 | 1085 | tags=50%, list=8%, signal=46% | Ramp2/Rap1a/Ceacam1/Kdr/Asb4 |
| GO:0010717 | GO:0010717 | regulation of epithelial to mesenchymal transition | 72 | -0.5113996 | -1.774745 | 0.0006568 | 0.0314002 | 0.0281824 | 1789 | tags=35%, list=14%, signal=30% | Glipr2/Sdhaf2/Phldb2/Clasp2/Tgfbr3/Crb2/Tgfbr2/Adipor1/Hpn/Efna1/Bambi/Hdac2/Mcrip1/Pofut2/Ezh2/Jag1/Sdcbp/Foxa2/Acvr1/Bmp2/Foxa1/Zfp703/Spred1/Snai1/Bmp7 |
| GO:0061036 | GO:0061036 | positive regulation of cartilage development | 17 | -0.7195583 | -1.832568 | 0.0007178 | 0.0340110 | 0.0305257 | 1076 | tags=35%, list=8%, signal=32% | Ccn1/Pkdcc/Por/Bmp2/Smad1/Wnt5a |
| GO:0044794 | GO:0044794 | positive regulation by host of viral process | 13 | -0.7878345 | -1.877522 | 0.0007378 | 0.0346487 | 0.0310981 | 1442 | tags=46%, list=11%, signal=41% | Vapb/Nucks1/Apoe/Ceacam1/Vapa/Ppib |
| GO:0120254 | GO:0120254 | olefinic compound metabolic process | 43 | -0.5836995 | -1.827014 | 0.0007446 | 0.0346652 | 0.0311128 | 1704 | tags=33%, list=13%, signal=28% | Gstm7/Scp2/Afp/Ttr/Cyp2s1/Bco1/Bmp2/Egr1/Rdh11/Gpx4/Rdh13/Alox15/Rbp4/Rbp1 |
| GO:0034063 | GO:0034063 | stress granule assembly | 26 | 0.6605162 | 1.927862 | 0.0007774 | 0.0355665 | 0.0319218 | 1614 | tags=42%, list=13%, signal=37% | D1Pas1/Grb7/Bicd1/Prrc2c/Ddx6/Ubap2l/Dync1h1/C9orf72/Rps23/Pum2/G3bp2 |
| GO:0003309 | GO:0003309 | type B pancreatic cell differentiation | 20 | -0.7071450 | -1.866815 | 0.0008118 | 0.0363673 | 0.0326405 | 439 | tags=30%, list=3%, signal=29% | Cdh2/Hnf4a/Bad/Dll1/Wnt5a/Gata6 |
| GO:0072001 | GO:0072001 | renal system development | 227 | -0.3827858 | -1.540075 | 0.0008155 | 0.0363673 | 0.0326405 | 2188 | tags=25%, list=17%, signal=21% | Sox17/Fbn1/Adamts1/Rdh10/Aqp11/Sall1/Hey1/Glis2/Bmper/Fgfr1/Stra6/Akr1b3/Sec61a1/Cited1/Rhoa/Pdgfa/Id3/Zmpste24/Tsc1/Tmem67/Odc1/Six4/Ap1b1/Crlf1/Id2/Pcsk5/Gpc3/Hes1/Pkd1/Efnb2/Slit2/Wnk4/Pygo2/Epha4/Vcan/Gcnt1/Arl3/Jag1/Bmp2/Pbx1/Hspb11/Ptcd2/Dll1/Egr1/Ctnnbip1/Lhx1/Smad6/Pdgfra/Ret/Rbp4/Lgr5/Cd24a/Tiparp/Cer1/Smad1/Wnt5a/Bmp7 |
| GO:0006517 | GO:0006517 | protein deglycosylation | 10 | -0.8397826 | -1.866254 | 0.0008558 | 0.0376098 | 0.0337557 | 1642 | tags=60%, list=13%, signal=52% | Aga/Edem2/Man2a1/Oga/Edem1/Ngly1 |
| GO:0003197 | GO:0003197 | endocardial cushion development | 34 | -0.6283989 | -1.878272 | 0.0008799 | 0.0379661 | 0.0340754 | 1990 | tags=44%, list=15%, signal=37% | Hey1/Bmpr2/Cited2/Bmpr1a/Tgfbr2/Gata4/Jag1/Thbs1/Acvr1/Bmp2/Msx2/Aplnr/Snai1/Msx1/Bmp7 |
| GO:0043407 | GO:0043407 | negative regulation of MAP kinase activity | 47 | -0.5679850 | -1.820029 | 0.0008967 | 0.0383021 | 0.0343771 | 1366 | tags=21%, list=11%, signal=19% | Dusp10/Gsk3b/Sh2b3/Apoe/Bmp2/Dnaja1/Hipk3/Dusp1/Aida/Bmp7 |
| GO:0050767 | GO:0050767 | regulation of neurogenesis | 313 | -0.3492185 | -1.449492 | 0.0009044 | 0.0383021 | 0.0343771 | 1396 | tags=18%, list=11%, signal=16% | Marcks/Bmpr1a/Ywhah/Dusp10/Id2/Gsk3b/Hes1/Qk/Cdk5/Xrcc2/Slit2/Dnajb11/Ppp1cc/Fmr1/Reln/Man2a1/Rnf10/Epha4/Apoe/Cdkl5/Trim32/Plxna2/Ifrd1/Chd7/Tenm4/Trim46/Trf/Hdac2/Ezh2/Cx3cl1/Egr2/Nin/Ntn1/Bmp2/Efnb3/Tnfrsf1b/Kdr/Dll1/Nptn/Wnt2/Pias2/Picalm/Sh3glb1/Fn1/Hmga2/Tmem98/Cd24a/Rab11a/Dll3/Wnt3/Zeb2/Prtg/Wnt5a/Tiam2/Id1/Bmp7 |
| GO:0060419 | GO:0060419 | heart growth | 80 | -0.4872175 | -1.715124 | 0.0009470 | 0.0386854 | 0.0347211 | 2100 | tags=31%, list=16%, signal=26% | Col14a1/Cdk1/Pak1/Map2k4/Fgfr1/Tomm70a/Cited2/Prox1/Bmpr1a/Tgfbr3/Slc25a4/Gsk3b/Tgfbr2/Ripk1/Ncam1/Gata4/Heg1/Tenm4/Hdac2/Dusp6/Wnt2/Rbp4/Mesp1/Smad1/Gata6 |
| GO:0009948 | GO:0009948 | anterior/posterior axis specification | 43 | -0.5769441 | -1.805869 | 0.0009664 | 0.0386854 | 0.0347211 | 988 | tags=28%, list=8%, signal=26% | Tmed2/Aurka/Hhex/Foxa2/Lhx1/Wls/Mesp1/Tdgf1/Cer1/Wnt3/Wnt5a/Mesp2 |
| GO:0060038 | GO:0060038 | cardiac muscle cell proliferation | 45 | -0.5716832 | -1.816702 | 0.0009805 | 0.0386854 | 0.0347211 | 2032 | tags=33%, list=16%, signal=28% | Cdk1/Fgfr1/Cited2/Bmpr1a/Tgfbr3/Tgfbr2/Ripk1/Ncam1/Gata4/Tenm4/Hdac2/Wnt2/Rbp4/Smad1/Gata6 |
| GO:0016570 | GO:0016570 | histone modification | 383 | 0.3188695 | 1.395038 | 0.0009861 | 0.0386854 | 0.0347211 | 2005 | tags=21%, list=16%, signal=19% | Tet1/Pml/Akap8l/Sin3a/Phc1/Ep400/Hcfc1/Trerf1/Usp21/Bend3/Nelfe/Dnmt3b/Dppa2/Kmt2a/Usp7/Kdm3a/Dtx3l/Nos1/Arrb1/Tet3/Taf1/Wdr5b/Arid4a/Setd2/Asxl1/Kdm5a/Elk4/Kdm4a/Rest/Hdac11/Per1/Baz2a/Phf8/Kmt2d/Jade2/Ruvbl2/Rif1/Jmjd1c/Brd8/Kansl3/Setd7/Sirt6/Hlcs/Snca/Tada3/Hdac4/Trrap/H1f4/Kdm4c/Ehmt1/App/Supt6/Ep300/Bcor/Setd4/Rtf1/Nsd3/Atrx/Setd5/Ing3/Huwe1/Nsd1/Hdac1/Zfp110/Chtop/L3mbtl2/Crtc2/Jarid2/Pcgf2/Iws1/Zfp335/Brca1/Incenp/Paxbp1/Smarcad1/Hdac10/Leo1/Parp2/Wbp2/Eya3/Kdm2a/Dnmt1 |
| GO:0002684 | GO:0002684 | positive regulation of immune system process | 427 | -0.3276101 | -1.398754 | 0.0009862 | 0.0386854 | 0.0347211 | 1688 | tags=17%, list=13%, signal=15% | Hmgb1/Atp11c/Tmem64/Nck1/Fes/Rhoa/Shld1/Shld3/B2m/Lgmn/Snx4/Akirin2/Dusp22/Bloc1s6/Hexim1/Ror2/Dusp10/Id2/Elf1/Gsk3b/Pqbp1/Hes1/Efnb2/Pomc/Xbp1/Map3k7/Plcl2/Ninj1/Rabgef1/Creb3/Cd38/Tgfbr2/Stx7/Ripk1/Dnajb9/Hmces/Selenok/Adora2b/Ptpn2/Ptger4/Rap1a/Malt1/Cx3cl1/Thbs1/Ceacam1/Efnb3/Calr/Bcl10/Mcu/Bad/Khdrbs1/Klf10/Rac1/Lamp1/Ube2n/Foxj1/Ctnnbip1/Aqp3/Cr1l/Lgals8/Jun/Rbp4/Cd24a/Ifi204/Rftn1/Cyba/Cmtm3/Efnb1/Mbl2/Wnt5a/Cyrib/Klhl6/Fos |
| GO:0050678 | GO:0050678 | regulation of epithelial cell proliferation | 233 | -0.3732878 | -1.502757 | 0.0009875 | 0.0386854 | 0.0347211 | 1688 | tags=23%, list=13%, signal=20% | Hmgb1/Stxbp4/Itpr1/B2m/Prox1/Npm1/Mydgf/Pdcd6/Birc5/Bmpr1a/Six4/Tgfbr3/Dusp10/Apela/Fgfbp1/Gpc3/Hes1/Efnb2/Rreb1/Xbp1/Pdcl3/Pygo2/Ctsl/Apoe/Hpn/Pold4/Cdc73/Emc10/Adora2b/Intu/Rida/Ppp1r16b/Pdcd10/Thbs1/Ceacam1/Bmp2/Bad/Pex2/Kdr/Cdc42/Mcc/Zfp703/Wnt2/Apln/Aimp1/Aplnr/Ccnd2/Hmga2/Jun/Gas1/Cyba/Wnt5a/Id1 |
| GO:0003156 | GO:0003156 | regulation of animal organ formation | 22 | -0.6971547 | -1.888980 | 0.0009895 | 0.0386854 | 0.0347211 | 579 | tags=27%, list=5%, signal=26% | Fgf3/Bmp2/Wnt2/Mesp1/Wnt5a/Bmp7 |
| GO:0060572 | GO:0060572 | morphogenesis of an epithelial bud | 13 | -0.7816586 | -1.862804 | 0.0009914 | 0.0386854 | 0.0347211 | 541 | tags=31%, list=4%, signal=30% | Hhex/Wnt2/Wnt5a/Bmp7 |
| GO:0022409 | GO:0022409 | positive regulation of cell-cell adhesion | 151 | -0.4158103 | -1.596305 | 0.0010418 | 0.0400650 | 0.0359593 | 1688 | tags=21%, list=13%, signal=18% | Hmgb1/Cited2/Nck1/Rhoa/B2m/Dusp10/Hes1/Efnb2/Xbp1/Ets1/Tgfbr2/Selenok/Adam19/Chst2/Malt1/Cx3cl1/Ceacam1/Efnb3/Bcl10/Bad/Fgg/Fga/Fgb/Nfat5/Alox15/Lgals8/Cd24a/Efnb1/Wnt5a/Cyrib/Bmp7 |
| GO:0002521 | GO:0002521 | leukocyte differentiation | 341 | -0.3447442 | -1.444488 | 0.0010717 | 0.0409170 | 0.0367240 | 1725 | tags=18%, list=13%, signal=16% | Calca/Hmgb1/Atp11c/Tmem64/Cited2/Fes/Rhoa/B2m/Tsc1/Tmem176a/Gpr89/Ror2/Dusp10/Id2/Gpc3/Gsk3b/Tspan2/Kdelr1/Chuk/Hmgb3/Wwp1/Xbp1/Plcl2/Tusc2/Sh2b3/Ninj1/Ctsl/Tgfbr2/Cebpg/Rabl3/Ripk1/Dnajb9/Chd7/Ptpn2/Tcta/Trf/Tcf7/Ptger4/Malt1/Hhex/Tmem176b/Ezh2/Atg5/Ceacam1/Bad/Pbx1/Klf10/Dll1/Egr1/Foxj1/Ctnnbip1/Lfng/Epha2/Lgals8/Eomes/Tmem98/Jun/Cd24a/Ifi204/Rbp1/Fos |
| GO:0061756 | GO:0061756 | leukocyte adhesion to vascular endothelial cell | 26 | -0.6559969 | -1.874527 | 0.0010907 | 0.0413436 | 0.0371068 | 2192 | tags=50%, list=17%, signal=42% | Ext1/Golph3/Pawr/St3gal4/Rock1/Slc39a8/Rhoa/Ets1/Gcnt1/Chst2/Nfat5/Itgb7/Klf4 |
| GO:0071277 | GO:0071277 | cellular response to calcium ion | 47 | -0.5604079 | -1.795750 | 0.0011146 | 0.0419509 | 0.0376519 | 561 | tags=13%, list=4%, signal=12% | Spag16/Alox15/Rasa4/Jun/Fosb/Fos |
| GO:0035914 | GO:0035914 | skeletal muscle cell differentiation | 43 | -0.5726603 | -1.792460 | 0.0012059 | 0.0449884 | 0.0403781 | 1981 | tags=28%, list=15%, signal=24% | Foxn2/Cops2/Cited2/Hlf/Six4/Med20/Atf3/Gata4/Egr2/Egr1/Eomes/Fos |
| GO:0035270 | GO:0035270 | endocrine system development | 75 | -0.4886432 | -1.703455 | 0.0012698 | 0.0461910 | 0.0414575 | 1955 | tags=24%, list=15%, signal=20% | Map2k2/Stra6/Cdh2/Cited2/Bmpr1a/Hes1/Hnf4a/Apoa1/Hhex/Foxa2/Bmp2/Bad/Pbx1/Dll1/Hmga2/Pdgfra/Wnt5a/Gata6 |
| GO:0006346 | GO:0006346 | DNA methylation-dependent heterochromatin assembly | 17 | 0.7057703 | 1.858525 | 0.0012717 | 0.0461910 | 0.0414575 | 2233 | tags=47%, list=17%, signal=39% | Tet1/Dnmt3a/Dnmt3b/Atf7ip/Hdac1/Morc2a/Dnmt1/Smarca4 |
| GO:1900017 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response | 10 | 0.8138269 | 1.871494 | 0.0012974 | 0.0465211 | 0.0417538 | 783 | tags=40%, list=6%, signal=38% | Il17rc/Cd6/Kpna6/Myd88 |
| GO:0198738 | GO:0198738 | cell-cell signaling by wnt | 340 | -0.3331548 | -1.396335 | 0.0013331 | 0.0473671 | 0.0425131 | 1867 | tags=19%, list=15%, signal=17% | Ryk/Lats2/Ddit3/Bcl7b/Zbtb33/Cdh2/Sdhaf2/Tmem64/Prickle1/Nkd2/Ppm1a/Ube2b/Peg12/Fzd10/Ror2/Cpe/Gpc3/Snx3/Gsk3b/Mark1/Pkd1/Cul3/Tpbg/Fzd2/Adgra2/Pygo2/Fzd4/Ccnyl1/Apoe/Wdr61/Cdc73/Amfr/Bambi/Lect2/Hdac2/Tcf7/Nkd1/Hhex/Ccny/Fzd1/Bmp2/Rac1/Mesd/Mcc/Frat1/Egr1/Zfp703/Lrrfip2/Wnt2/Znrf3/Gsc/Ctnnbip1/Tle3/Dact1/Wls/Hmga2/Lgr5/Mesp1/Wnt5b/Wnt3/Frzb/Zeb2/Etv2/Wnt5a/Klf4 |
| GO:1904948 | GO:1904948 | midbrain dopaminergic neuron differentiation | 12 | -0.7877627 | -1.827883 | 0.0013477 | 0.0473671 | 0.0425131 | 383 | tags=42%, list=3%, signal=40% | Ryk/Rac1/Wnt2/Wnt3/Wnt5a |
| GO:0070988 | GO:0070988 | demethylation | 47 | 0.5433482 | 1.762977 | 0.0013601 | 0.0474870 | 0.0426207 | 1093 | tags=26%, list=8%, signal=23% | Tet1/Usp7/Kdm3a/Tet3/Kdm5a/Kdm4a/Phf8/Jmjd1c/Apobec3/Kdm4c/Fto/Apobec2 |
| GO:0071560 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 159 | -0.3999840 | -1.548726 | 0.0013818 | 0.0477456 | 0.0428528 | 1840 | tags=20%, list=14%, signal=17% | Lats2/Bmpr1b/Pbld1/Cited2/Zyx/Cited1/Ppm1a/Strap/Dusp22/Tgfbr3/Hspa5/Twsg1/Xbp1/Map3k7/Tgfbr2/Fbn2/Emilin1/Bambi/Nrep/Sdcbp/Thbs1/Acvr1/Bmp2/Snx6/Zfp703/Spred1/Smad6/Jun/Tdgf1/Smad1/Zeb2/Fos |
| GO:0034976 | GO:0034976 | response to endoplasmic reticulum stress | 224 | -0.3698352 | -1.486502 | 0.0013855 | 0.0477456 | 0.0428528 | 2144 | tags=27%, list=17%, signal=23% | Erlin2/Aqp11/Eif2b5/Eif2s1/Tmem129/Hsp90b1/Creb3l3/Tmtc4/Tmem259/Nploc4/Ddit3/Abca7/Crebrf/Nck1/Itpr1/Herpud2/Tmem67/Yod1/Lpcat3/Vapb/Ubxn4/Rnf139/Erlec1/Hspa5/Gsk3b/Jkamp/Rnft1/Ubxn8/Xbp1/Edem2/Creb3/Ppp1r15a/Tmed2/Atf3/Manf/Edem1/Derl2/Amfr/Tmub2/Selenos/Bcl2l1/Serp1/Dnajb9/Selenok/Stt3b/Ptpn2/Psmc6/Pmp22/Ngly1/Thbs1/Calr/Erp44/Pdia3/Sdf2l1/Dnajb2/Tmco1/Alox15/Trim13/Bfar/Jun/Txndc12 |
| GO:0043542 | GO:0043542 | endothelial cell migration | 148 | -0.4102422 | -1.577232 | 0.0014098 | 0.0482708 | 0.0433242 | 2470 | tags=30%, list=19%, signal=24% | Dpp4/Synj2bp/Plpp3/Prkca/Met/Sash1/Stat5a/Fstl1/Cib1/Bmper/Fgfr1/Bmpr2/Calca/Hmgb1/Rhoa/Lgmn/Prox1/Pdcd6/Svbp/Fgfbp1/Rhob/Adamts9/Efnb2/Slit2/Apoa1/Ets1/Adgra2/Apoe/Rock2/Emc10/Efna1/Adora2b/Itgav/Pdcd10/Thbs1/Ceacam1/Calr/Kdr/Rac1/Spred1/Epha2/Lgals8/Wnt5a/Klf4 |
| GO:0007492 | GO:0007492 | endoderm development | 62 | -0.5224848 | -1.769963 | 0.0014393 | 0.0486507 | 0.0436652 | 1394 | tags=29%, list=11%, signal=26% | Bmpr1a/Pelo/Cfc1/Cdc73/Gata4/Col5a2/Itgav/Hhex/Foxa2/Lhx1/Fn1/Hmga2/Eomes/Mesp1/Mixl1/Dusp5/Dusp1/Gata6 |
| GO:1901722 | GO:1901722 | regulation of cell proliferation involved in kidney development | 10 | -0.8307599 | -1.846203 | 0.0014582 | 0.0489773 | 0.0439583 | 317 | tags=20%, list=2%, signal=20% | Egr1/Bmp7 |
| GO:0061448 | GO:0061448 | connective tissue development | 166 | -0.4012905 | -1.560056 | 0.0014923 | 0.0498082 | 0.0447041 | 2311 | tags=26%, list=18%, signal=22% | Thra/Sh3pxd2b/Sik3/Prkca/Snx19/Pbxip1/Lnpk/Fgfr1/Bmpr1b/Bmpr2/Pth1r/Zmpste24/Csgalnact1/Sptlc2/Bpnt2/Bmpr1a/Ror2/Id2/Tapt1/Pkd1/Xbp1/Pik3ca/Ccn1/Ap1s2/Tgfbr2/Col9a1/Pkdcc/Por/Foxa2/Thbs1/Bmp2/Foxa1/Msx2/Egr1/Zfp516/Hmga2/Snai1/Cer1/Msx1/Smad1/Frzb/Wnt5a/Bmp7 |
| GO:0045639 | GO:0045639 | positive regulation of myeloid cell differentiation | 62 | -0.5220957 | -1.768645 | 0.0015058 | 0.0499461 | 0.0448278 | 2287 | tags=35%, list=18%, signal=29% | Prkca/Stat5a/Dlk1/Slc9b2/Calca/Hmgb1/Tmem64/Fes/Ror2/Id2/Gsk3b/Ets1/Ninj1/Pithd1/Ripk1/Rcor1/Jag1/Klf10/Ankrd54/Ctnnbip1/Jun/Fos |
| ID | Description | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalues | rank | leading_edge | core_enrichment | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GO:0140657 | GO:0140657 | ATP-dependent activity | 423 | 0.3598583 | 1.575543 | 0.0000031 | 0.0028130 | 0.0025753 | 3328 | tags=34%, list=26%, signal=26% | 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 |
| GO:0004386 | GO:0004386 | helicase activity | 145 | 0.4525863 | 1.773142 | 0.0000248 | 0.0114367 | 0.0104701 | 3348 | tags=42%, list=26%, signal=31% | Nav2/Zgrf1/Chd9/D1Pas1/Tdrd12/Setx/Ep400/Recql5/Shprh/Ddx46/Chd2/Ddx6/Ddx55/Ddx17/Rfc5/Ruvbl2/Hltf/Chd6/Helq/Ddx42/Ttf2/Ascc3/Ddx56/Recql4/Aqr/Atrx/Rtel1/Smarcad1/Ddx41/Xrcc6/Dhx30/Helz/Skiv2l/Ddx11/Rad54l/Smarca4/Ruvbl1/Fbh1/Znfx1/Dhx33/Ddx10/Zranb3/Ddx1/Ddx23/Dhx34/Ddx31/Recql/Chtf8/Wrnip1/Chtf18/Fancm/Dna2/Dhx57/Rad54l2/Mcm3/Dhx8/Mcm5/Ddx27/Mcm6/Twnk/Mov10l1 |
| GO:0070412 | GO:0070412 | R-SMAD binding | 20 | -0.7692986 | -2.047432 | 0.0000619 | 0.0186577 | 0.0170807 | 140 | tags=20%, list=1%, signal=20% | Smad6/Jun/Zeb2/Fos |
| GO:0008094 | GO:0008094 | ATP-dependent activity, acting on DNA | 103 | 0.4794104 | 1.791785 | 0.0000810 | 0.0186577 | 0.0170807 | 3328 | tags=48%, list=26%, signal=36% | Nav2/Chd9/D1Pas1/Ep400/Recql5/Shprh/Chd2/Rad51b/Rfc5/Ruvbl2/Hltf/Bptf/Chd6/Helq/Atad5/Rad54b/Ttf2/Xrcc3/Ascc3/Recql4/Atrx/Rtel1/Dmc1/Msh2/Msh6/Smarcad1/Xrcc6/Ddx11/Rad54l/Smarca4/Ruvbl1/Fbh1/Rad51d/Zranb3/Msh3/Rfc1/Ddx1/Recql/Chtf8/Wrnip1/Chtf18/Fancm/Dna2/Rad54l2/Mcm3/Mcm5/Cecr2/Mcm6/Twnk |
| GO:0140097 | GO:0140097 | catalytic activity, acting on DNA | 203 | 0.3942711 | 1.613714 | 0.0001352 | 0.0249115 | 0.0228060 | 3328 | tags=39%, list=26%, signal=29% | Nav2/Dnmt3a/Zgrf1/Dclre1b/Chd9/Ogg1/D1Pas1/Ep400/Recql5/Shprh/Dnmt3b/Chd2/Pola2/Lig1/Rad51b/Pole/Rfc5/Ruvbl2/Hltf/Bptf/Exo1/Chd6/Ung/Fto/Helq/Atad5/Rad54b/Ttf2/Xrcc3/Dkc1/Ascc3/Slx4/Recql4/Atrx/Rtel1/Dmc1/Msh2/Msh6/Smarcad1/Xrcc6/Top3b/Dnmt1/Endov/Ddx11/Tep1/Xrcc1/Rad54l/Smarca4/Ruvbl1/Fbh1/Polk/Rad51d/Zranb3/Dclre1a/Msh3/Alkbh3/Pola1/Setmar/Rfc1/Ddx1/Lig3/Terf2/Pold1/Recql/Chtf8/Mutyh/Tdp1/Wrnip1/Chtf18/Fancm/Dna2/Rad54l2/Dclre1c/Mcm3/Mcm5/Dnase2a/Cecr2/Mcm6/Twnk |
| ID | Description | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalues | rank | leading_edge | core_enrichment | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GO:0022626 | GO:0022626 | cytosolic ribosome | 101 | 0.5513864 | 2.039457 | 0.0000003 | 0.0002136 | 0.0001986 | 3187 | tags=47%, list=25%, signal=35% | Rps28/D1Pas1/Rpl37/Rpl24/Rps29/Rpl36/Rps21/Rpl41/Rplp2/Rpl38/Rpl37a/Rps26/Rpl37rt/Rps8/Rpl39l/Eif2ak4/Rps10/Rps27/Rps27rt/Rps15/Rpl9-ps6/Rps17/Rpl28/Fau/Rps16/Rps23/Rpl36a/Rpl10l/Rpl34/Rpl10a/Rps12/Rplp1/Rpl39/Rpl29/Rpl35a/Rpl26/Rps18/Uba52/Rpl35/Larp4/Rpl23a/Rpl3/Rpl13a/Eif2d/Rpl18/Rpl32/Rpl30 |
| GO:0140534 | GO:0140534 | endoplasmic reticulum protein-containing complex | 114 | -0.5357449 | -1.965422 | 0.0000019 | 0.0006029 | 0.0005606 | 2874 | tags=41%, list=22%, signal=32% | P4ha1/Pdia4/Sec63/Fam8a1/Pigu/Pigk/Insig2/P4hb/Pdia6/Arl6ip1/Alg14/Magt1/Caml/Hsp90b1/Nploc4/Sptssa/Ddost/Pigm/Ormdl1/Sec61a1/B2m/Sec11a/Sptlc2/Rnf139/Spcs2/Hspa5/Mmgt1/Dnajb11/Emc10/Derl2/Amfr/Selenos/Arxes1/Stt3b/Spcs3/Pyurf/Emc6/Mmgt2/Calr/Ostc/Emc7/Pdia3/Sdf2l1/Hsd17b12/Spcs1/Ppib/Emc2 |
| GO:0098827 | GO:0098827 | endoplasmic reticulum subcompartment | 469 | -0.3612751 | -1.549684 | 0.0000086 | 0.0018645 | 0.0017335 | 2220 | tags=26%, list=17%, signal=22% | Tmem33/Sdf2/Alg14/Ankle2/Lpcat2/Selenoi/Erlin2/Dolk/Magt1/Caml/Abcd1/Jagn1/Osbpl8/Hsp90b1/Creb3l3/Kdelr2/Lnpk/Triqk/Nploc4/Rce1/Sgms2/Sptssa/Ddost/Rab2a/Lrrc8e/Rab18/Ormdl1/Sec61a1/Itpr1/Abhd12/Alg12/Tex264/B2m/Zmpste24/Sec11a/Dpagt1/Tmem67/Zdhhc2/Stard3nl/Slc35b1/Cnih4/Sptlc2/Gpsm1/Lpcat3/Vapb/Rab1a/Rnf139/Spcs2/Hspa5/Vti1b/Tapt1/Soat2/Elovl1/Sec22b/Kdelr1/Mmgt1/Bcap29/Ubxn8/Esyt2/Xbp1/Cyb5a/Sppl2a/Hacd2/Creb3/Ppp1r15a/Rft1/Vti1a/Tmed2/Hpn/Rtn3/Edem1/Emc10/Derl2/Amfr/Tmem39a/Selenos/Ssr1/Arxes1/Selenok/Stt3b/Vmp1/Spcs3/Pyurf/Emc6/Mmgt2/Pdzd8/Agpat3/Cept1/Slc37a4/Reep5/Lmbrd1/Dtnbp1/Calr/Pigf/Ostc/Emc7/Erp44/Saraf/Pdia3/Sdf2l1/Kdelr3/Dnajb2/Hsd17b12/Cisd2/Rdh11/Tmco1/Tram1/Vapa/Sri/Trim13/Wls/Retreg1/Gramd1a/Yif1a/Spcs1/Tmem98/Alg5/C2cd2l/Vma21/Emc2 |
| GO:0022627 | GO:0022627 | cytosolic small ribosomal subunit | 45 | 0.6258982 | 2.003463 | 0.0000201 | 0.0032794 | 0.0030490 | 1524 | tags=31%, list=12%, signal=28% | Rps28/D1Pas1/Rps29/Rps21/Rps26/Rps8/Rps10/Rps27/Rps27rt/Rps15/Rps17/Fau/Rps16/Rps23 |
| GO:0005789 | GO:0005789 | endoplasmic reticulum membrane | 457 | -0.3542421 | -1.518713 | 0.0000357 | 0.0046208 | 0.0042962 | 2220 | tags=25%, list=17%, signal=22% | Tmem33/Sdf2/Alg14/Ankle2/Lpcat2/Selenoi/Erlin2/Dolk/Magt1/Caml/Abcd1/Jagn1/Hsp90b1/Creb3l3/Kdelr2/Lnpk/Triqk/Nploc4/Rce1/Sgms2/Sptssa/Ddost/Rab2a/Lrrc8e/Ormdl1/Sec61a1/Itpr1/Abhd12/Alg12/Tex264/B2m/Zmpste24/Sec11a/Dpagt1/Tmem67/Zdhhc2/Stard3nl/Slc35b1/Cnih4/Sptlc2/Gpsm1/Lpcat3/Vapb/Rab1a/Rnf139/Spcs2/Hspa5/Vti1b/Tapt1/Soat2/Elovl1/Sec22b/Kdelr1/Mmgt1/Bcap29/Ubxn8/Esyt2/Xbp1/Cyb5a/Sppl2a/Hacd2/Creb3/Ppp1r15a/Rft1/Vti1a/Tmed2/Hpn/Rtn3/Edem1/Emc10/Derl2/Amfr/Tmem39a/Selenos/Ssr1/Arxes1/Selenok/Stt3b/Vmp1/Spcs3/Pyurf/Emc6/Mmgt2/Pdzd8/Agpat3/Cept1/Slc37a4/Lmbrd1/Dtnbp1/Calr/Pigf/Ostc/Emc7/Erp44/Saraf/Pdia3/Sdf2l1/Kdelr3/Dnajb2/Hsd17b12/Cisd2/Rdh11/Tmco1/Tram1/Vapa/Sri/Trim13/Wls/Retreg1/Gramd1a/Yif1a/Spcs1/Tmem98/Alg5/Vma21/Emc2 |
| GO:0042175 | GO:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | 478 | -0.3471302 | -1.491702 | 0.0000426 | 0.0046208 | 0.0042962 | 2220 | tags=25%, list=17%, signal=21% | Tmem33/Sdf2/Alg14/Ankle2/Lpcat2/Xpo1/Selenoi/Erlin2/Dolk/Magt1/Caml/Abcd1/Jagn1/Hsp90b1/Creb3l3/Kdelr2/Lnpk/Triqk/Nploc4/Rce1/Sgms2/Sptssa/Ddost/Rab2a/Lrrc8e/Ormdl1/Sec61a1/Itpr1/Abhd12/Alg12/Tex264/B2m/Zmpste24/Sec11a/Dpagt1/Tmem67/Zdhhc2/Stard3nl/Slc35b1/Cnih4/Sptlc2/Gpsm1/Lpcat3/Vapb/Rab1a/Rnf139/Spcs2/Hspa5/Vti1b/Tapt1/Cnep1r1/Mogat2/Soat2/Elovl1/Sec22b/Kdelr1/Mmgt1/Bcap29/Ubxn8/Esyt2/Xbp1/Cyb5a/Sppl2a/Hacd2/Creb3/Ppp1r15a/Rft1/Vti1a/Tmed2/Hpn/Rtn3/Edem1/Emc10/Derl2/Amfr/Tmem39a/Selenos/Ssr1/Arxes1/Selenok/Stt3b/Vmp1/Spcs3/Pyurf/Emc6/Mmgt2/Pdzd8/Agpat3/Cept1/Slc37a4/Lmbrd1/Dtnbp1/Calr/Pigf/Ostc/Emc7/Erp44/Saraf/Pdia3/Sdf2l1/Kdelr3/Dnajb2/Hsd17b12/Cisd2/Rdh11/Tmco1/Tram1/Vapa/Sri/Trim13/Wls/Retreg1/Gramd1a/Yif1a/Spcs1/Tmem98/Alg5/Vma21/Emc2 |
| GO:0031300 | GO:0031300 | intrinsic component of organelle membrane | 306 | -0.3628567 | -1.492749 | 0.0001436 | 0.0131136 | 0.0121923 | 2868 | tags=33%, list=22%, signal=26% | Slc35a4/Ext1/Elovl5/Tmem11/Atp2c1/Slc35b2/Rtn4/Spg7/Acer3/Elovl2/Pigu/Pigk/Insig2/Sgms1/Arl6ip1/Pex13/Casd1/Spire1/Synj2bp/Pgap3/Stx12/Steap2/Fis1/Stx6/Ptpmt1/Acer2/Tmem33/Ankle2/Dolk/Tmem43/Caml/Abcd1/Itm2b/Lnpk/Tomm70a/Rce1/Sgms2/Lrrc8e/Slc66a1/B4galnt2/B2m/Zmpste24/Slc35b1/Micu1/Pcsk5/Hspa5/Tvp23b/Pex3/Tapt1/Pomgnt1/Mpc1/Elovl1/Mmgt1/Coq2/Ubxn8/Esyt2/Golga7/Xbp1/Coa3/Fundc1/Sppl2a/Tomm20/Hacd2/Creb3/Rer1/Edem1/Slc25a17/Mff/Etfdh/Tmem70/Emc10/Derl2/Amfr/Selenos/Apool/Bet1/Emc6/Mmgt2/Slc37a4/Calr/Mcu/Pex2/Emc7/Saraf/Pdia3/Lamp2/Pex11a/Dnajb2/Slc35a1/Tmco1/Tram1/Lfng/Wls/Retreg1/Gramd1a/Chchd3/Yif1a/Spcs1/Mpc2/Emc2 |
| GO:0061700 | GO:0061700 | GATOR2 complex | 10 | 0.8504094 | 1.907741 | 0.0001612 | 0.0131136 | 0.0121923 | 189 | tags=20%, list=1%, signal=20% | Szt2/Castor1 |
| GO:0090575 | GO:0090575 | RNA polymerase II transcription regulator complex | 147 | -0.4469639 | -1.691310 | 0.0001828 | 0.0132247 | 0.0122956 | 1030 | tags=14%, list=8%, signal=13% | Pygo2/Taf13/Rxrg/Taf4b/Gata4/Tcf7/Lmo4/Taf10/Pbx1/Ccnh/Tle3/Mxd4/Med31/Smad6/Jun/Gtf2e2/Gtf2f2/Smad1/Gtf2b/Fos |
| GO:0042788 | GO:0042788 | polysomal ribosome | 34 | 0.6248012 | 1.869048 | 0.0003387 | 0.0219024 | 0.0203636 | 528 | tags=26%, list=4%, signal=25% | Rps28/Larp4b/Rpl24/Rps29/Rpl36/Rps21/Rpl41/Rpl38/Rps26 |
| GO:0016459 | GO:0016459 | myosin complex | 32 | 0.6390646 | 1.875896 | 0.0003701 | 0.0219024 | 0.0203636 | 2013 | tags=44%, list=16%, signal=37% | Cgnl1/Myo19/Myh9/Myo9a/Mlph/Bmf/Cgn/Myo5a/Myh10/Mylpf/Myh6/Myo18a/Myh7b/Myo1d |
| GO:0072546 | GO:0072546 | EMC complex | 11 | -0.8043551 | -1.829172 | 0.0010316 | 0.0447729 | 0.0416273 | 1223 | tags=55%, list=10%, signal=49% | Mmgt1/Emc10/Emc6/Mmgt2/Emc7/Emc2 |
1.1 FIGURE
sessionInfo()## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.6 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=it_IT.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=it_IT.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=it_IT.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=it_IT.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] tidytext_0.3.4 DOSE_3.20.1
## [3] GOSemSim_2.20.0 enrichplot_1.14.2
## [5] org.Mm.eg.db_3.14.0 AnnotationDbi_1.56.2
## [7] clusterProfiler_4.2.2 data.table_1.14.6
## [9] vsn_3.62.0 ggrepel_0.9.2
## [11] ggplot2_3.4.0 DESeq2_1.34.0
## [13] SummarizedExperiment_1.24.0 Biobase_2.54.0
## [15] MatrixGenerics_1.6.0 matrixStats_0.62.0
## [17] GenomicRanges_1.46.1 GenomeInfoDb_1.30.1
## [19] IRanges_2.28.0 S4Vectors_0.32.4
## [21] BiocGenerics_0.40.0
##
## loaded via a namespace (and not attached):
## [1] shadowtext_0.1.2 fastmatch_1.1-3 plyr_1.8.8
## [4] igraph_1.3.5 lazyeval_0.2.2 splines_4.1.3
## [7] BiocParallel_1.28.3 SnowballC_0.7.0 digest_0.6.30
## [10] yulab.utils_0.0.5 htmltools_0.5.3 viridis_0.6.2
## [13] GO.db_3.14.0 fansi_1.0.3 magrittr_2.0.3
## [16] memoise_2.0.1 limma_3.50.3 Biostrings_2.62.0
## [19] annotate_1.72.0 graphlayouts_0.8.3 colorspace_2.0-3
## [22] blob_1.2.3 xfun_0.35 dplyr_1.0.10
## [25] crayon_1.5.2 RCurl_1.98-1.9 jsonlite_1.8.3
## [28] scatterpie_0.1.8 genefilter_1.76.0 survival_3.2-13
## [31] ape_5.6-2 glue_1.6.2 polyclip_1.10-4
## [34] gtable_0.3.1 zlibbioc_1.40.0 XVector_0.34.0
## [37] DelayedArray_0.20.0 scales_1.2.1 DBI_1.1.3
## [40] Rcpp_1.0.9 viridisLite_0.4.1 xtable_1.8-4
## [43] gridGraphics_0.5-1 tidytree_0.4.1 bit_4.0.5
## [46] preprocessCore_1.56.0 httr_1.4.4 fgsea_1.20.0
## [49] RColorBrewer_1.1-3 pkgconfig_2.0.3 XML_3.99-0.12
## [52] farver_2.1.1 sass_0.4.2 locfit_1.5-9.6
## [55] utf8_1.2.2 ggplotify_0.1.0 tidyselect_1.2.0
## [58] labeling_0.4.2 rlang_1.0.6 reshape2_1.4.4
## [61] munsell_0.5.0 tools_4.1.3 cachem_1.0.6
## [64] downloader_0.4 cli_3.4.1 generics_0.1.3
## [67] RSQLite_2.2.18 evaluate_0.18 stringr_1.4.1
## [70] fastmap_1.1.0 yaml_2.3.6 ggtree_3.2.1
## [73] knitr_1.40 bit64_4.0.5 tidygraph_1.2.2
## [76] purrr_0.3.5 KEGGREST_1.34.0 ggraph_2.1.0
## [79] nlme_3.1-155 aplot_0.1.8 DO.db_2.9
## [82] tokenizers_0.2.3 compiler_4.1.3 rstudioapi_0.14
## [85] png_0.1-7 affyio_1.64.0 treeio_1.18.1
## [88] tibble_3.1.8 tweenr_2.0.2 geneplotter_1.72.0
## [91] bslib_0.4.1 stringi_1.7.8 highr_0.9
## [94] lattice_0.20-45 Matrix_1.5-3 vctrs_0.5.1
## [97] pillar_1.8.1 lifecycle_1.0.3 BiocManager_1.30.22
## [100] jquerylib_0.1.4 bitops_1.0-7 patchwork_1.1.2
## [103] qvalue_2.26.0 R6_2.5.1 affy_1.72.0
## [106] gridExtra_2.3 janeaustenr_1.0.0 codetools_0.2-18
## [109] MASS_7.3-55 assertthat_0.2.1 withr_2.5.0
## [112] GenomeInfoDbData_1.2.7 parallel_4.1.3 grid_4.1.3
## [115] prettydoc_0.4.1 ggfun_0.0.8 tidyr_1.2.1
## [118] rmarkdown_2.18 ggforce_0.4.1