Data are the WT samples from GSE66582 (MII oocyte to inner cell mass) and GSE76505 (E3.5 to E7.5).

SRA samples metadata

Run Assay Type AvgSpotLen Bases BioProject BioSample Bytes Center Name Consent DATASTORE filetype DATASTORE provider DATASTORE region Developmental_Stage Experiment GEO_Accession (exp) Instrument LibraryLayout LibrarySelection LibrarySource Organism Platform ReleaseDate Sample Name source_name SRA Study Strain V27 V28 tech_rep biol_rep sample
SRR2927027 RNA-Seq 252 1505618352 PRJNA277361 SAMN04252370 734563258 GEO public sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX1424864 GSM1933936 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1933936 Oocyte SRP055882 C57BL/6N 1 1 MII_oocyte.1.1
SRR2927029 RNA-Seq 252 3728612916 PRJNA277361 SAMN04252372 1955898799 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX1424866 GSM1933938 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1933938 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 1 early_2-cell.1.1
SRR1840522 RNA-Seq 252 1832709816 PRJNA277361 SAMN03389626 965956007 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902557 GSM1625868 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625868 Inner cell mass SRP055882 C57BL/6N x DBA/2N 1 1 Inner_cell_mass.1.1
SRR1840527 RNA-Seq 252 1121294664 PRJNA277361 SAMN03389630 566534329 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902562 GSM1625873 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625873 Embryonic stem cell SRP055882 R1 1 1 Embryonic_stem_cell.1.1
SRR1840528 RNA-Seq 202 600945556 PRJNA277361 SAMN03389630 417228212 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902562 GSM1625873 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625873 Embryonic stem cell SRP055882 R1 2 1 Embryonic_stem_cell.1.2
SRR2927026 RNA-Seq 252 2992171644 PRJNA277361 SAMN04252369 1460250126 GEO public sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX1424863 GSM1933935 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1933935 Oocyte SRP055882 C57BL/6N 1 2 MII_oocyte.2.1
SRR2927028 RNA-Seq 252 5524592472 PRJNA277361 SAMN04252371 2806445654 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX1424865 GSM1933937 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1933937 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 2 early_2-cell.2.1
SRR1840523 RNA-Seq 252 2674843164 PRJNA277361 SAMN03389624 1343439363 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902558 GSM1625869 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625869 Inner cell mass SRP055882 C57BL/6N x DBA/2N 1 2 Inner_cell_mass.2.1
SRR1840529 RNA-Seq 252 903440160 PRJNA277361 SAMN03389627 475039817 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902563 GSM1625874 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625874 Embryonic stem cell SRP055882 R1 1 2 Embryonic_stem_cell.2.1
SRR1840530 RNA-Seq 202 403116250 PRJNA277361 SAMN03389627 288193981 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902563 GSM1625874 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625874 Embryonic stem cell SRP055882 R1 2 2 Embryonic_stem_cell.2.2
SRR1840526 RNA-Seq 252 1888218360 PRJNA277361 SAMN03389645 978153821 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 NA SRX902561 GSM1625872 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625872 Inner cell mass SRP055882 C57BL/6N x DBA/2N 1 3 Inner_cell_mass.3.1
SRR1840514 RNA-Seq 252 3938456340 PRJNA277361 SAMN03389635 1902319581 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 Zygote SRX902549 GSM1625860 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625860 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 1 Zygote.1.1
SRR1840515 RNA-Seq 252 2581746300 PRJNA277361 SAMN03389636 1339573424 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 Zygote SRX902550 GSM1625861 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625861 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 2 Zygote.2.1
SRR1840516 RNA-Seq 202 3543457538 PRJNA277361 SAMN03389625 2513508836 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 2-cell SRX902551 GSM1625862 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625862 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 1 2-cell.1.1
SRR1840517 RNA-Seq 202 2877212048 PRJNA277361 SAMN03389641 2034693002 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 2-cell SRX902552 GSM1625863 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625863 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 2 2-cell.2.1
SRR1840518 RNA-Seq 202 2410744760 PRJNA277361 SAMN03389623 1669664926 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 4-cell SRX902553 GSM1625864 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625864 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 1 4-cell.1.1
SRR1840519 RNA-Seq 202 2383437996 PRJNA277361 SAMN03389640 1649914560 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 4-cell SRX902554 GSM1625865 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625865 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 2 4-cell.2.1
SRR1840520 RNA-Seq 202 1930443300 PRJNA277361 SAMN03389632 1329140005 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 8-cell SRX902555 GSM1625866 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625866 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 1 8-cell.1.1
SRR1840521 RNA-Seq 202 5477128798 PRJNA277361 SAMN03389631 3729863384 GEO public fastq,sra gs,ncbi,s3 gs.US,ncbi.public,s3.us-east-1 8-cell SRX902556 GSM1625867 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2016-06-15 GSM1625867 Preimplantation embryo SRP055882 C57BL/6N x DBA/2N 1 2 8-cell.2.1
SRR3083897 RNA-Seq 252 4507552980 PRJNA307584 SAMN04383620 2273523829 GEO public sra,fastq s3 s3.us-east-1 E3.5_ICM SRX1515370 GSM2027204 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027204 Preimplantation embryo_E3.5 Inner cell mass SRP068043 Inner cell mass C57BL/6N x DBA/2N E3.5 1 1 E3.5_ICM.1.1
SRR3083898 RNA-Seq 252 1888218360 PRJNA307584 SAMN04383621 963780697 GEO public fastq,sra s3 s3.us-east-1 E3.5_ICM SRX1515371 GSM2027205 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027205 Preimplantation embryo_E3.5 Inner cell mass SRP068043 Inner cell mass C57BL/6N x DBA/2N E3.5 1 2 E3.5_ICM.2.1
SRR3083901 RNA-Seq 202 1394292880 PRJNA307584 SAMN04383624 908720321 GEO public sra,fastq s3 s3.us-east-1 E4.0_ICM SRX1515374 GSM2027208 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027208 Periimplantation embryo_E4.0 Inner cell mass SRP068043 Inner cell mass C57BL/6N x DBA/2N E4.0 1 1 E4.0_ICM.1.1
SRR3083902 RNA-Seq 252 8179791732 PRJNA307584 SAMN04383625 4931826482 GEO public sra,fastq s3 s3.us-east-1 E4.0_ICM SRX1515375 GSM2027209 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027209 Periimplantation embryo_E4.0 Inner cell mass SRP068043 Inner cell mass C57BL/6N x DBA/2N E4.0 1 2 E4.0_ICM.2.1
SRR3083903 RNA-Seq 250 848414500 PRJNA307584 SAMN04383626 337244005 GEO public sra,fastq s3 s3.us-east-1 E5.5_Epi SRX1515376 GSM2027210 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027210 postimplantation embryo_E5.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E5.5 1 1 E5.5_Epi.1.1
SRR3083904 RNA-Seq 202 1520482684 PRJNA307584 SAMN04383626 989997042 GEO public sra,fastq s3 s3.us-east-1 E5.5_Epi SRX1515376 GSM2027210 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027210 postimplantation embryo_E5.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E5.5 2 1 E5.5_Epi.1.2
SRR3083905 RNA-Seq 202 585782224 PRJNA307584 SAMN04383627 279520597 GEO public sra,fastq s3 s3.us-east-1 E5.5_Epi SRX1515377 GSM2027211 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027211 postimplantation embryo_E5.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E5.5 1 2 E5.5_Epi.2.1
SRR3083906 RNA-Seq 252 1666458612 PRJNA307584 SAMN04383627 593019530 GEO public sra,fastq s3 s3.us-east-1 E5.5_Epi SRX1515377 GSM2027211 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027211 postimplantation embryo_E5.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E5.5 2 2 E5.5_Epi.2.2
SRR3083909 RNA-Seq 252 3490153128 PRJNA307584 SAMN04383630 1723398838 GEO public fastq,sra s3 s3.us-east-1 E6.5_Epi SRX1515380 GSM2027214 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027214 postimplantation embryo_E6.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E6.5 1 1 E6.5_Epi.1.1
SRR3083910 RNA-Seq 202 4230148256 PRJNA307584 SAMN04383631 2930634705 GEO public sra,fastq s3 s3.us-east-1 E6.5_Epi SRX1515381 GSM2027215 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027215 postimplantation embryo_E6.5 Epiblast SRP068043 Epiblast C57BL/6N x DBA/2N E6.5 1 2 E6.5_Epi.2.1
SRR3083914 RNA-Seq 252 3396975624 PRJNA307584 SAMN04383634 1777732499 GEO public sra,fastq s3 s3.us-east-1 E7.5_Ecto SRX1515384 GSM2027218 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027218 postimplantation embryo_E7.5 Ectoderm SRP068043 Ectoderm C57BL/6N x DBA/2N E7.5 1 1 E7.5_Ecto.1.1
SRR3083915 RNA-Seq 202 2478181248 PRJNA307584 SAMN04383635 1608906057 GEO public fastq,sra s3 s3.us-east-1 E7.5_Ecto SRX1515385 GSM2027219 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027219 postimplantation embryo_E7.5 Ectoderm SRP068043 Ectoderm C57BL/6N x DBA/2N E7.5 1 2 E7.5_Ecto.2.1
SRR3083916 RNA-Seq 252 2788655688 PRJNA307584 SAMN04383637 1402005645 GEO public sra,fastq s3 s3.us-east-1 E7.5_PS SRX1515386 GSM2027220 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027220 postimplantation embryo_E7.5 Primitive streak SRP068043 Primitive streak C57BL/6N x DBA/2N E7.5 1 1 E7.5_PS.1.1
SRR3083917 RNA-Seq 252 3099133044 PRJNA307584 SAMN04383638 1547257476 GEO public sra,fastq s3 s3.us-east-1 E7.5_PS SRX1515387 GSM2027221 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027221 postimplantation embryo_E7.5 Primitive streak SRP068043 Primitive streak C57BL/6N x DBA/2N E7.5 1 2 E7.5_PS.2.1
SRR3083918 RNA-Seq 252 3580886232 PRJNA307584 SAMN04383639 1750971040 GEO public fastq,sra s3 s3.us-east-1 E7.5_Meso SRX1515388 GSM2027222 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027222 postimplantation embryo_E7.5 Mesoderm SRP068043 Mesoderm C57BL/6N x DBA/2N E7.5 1 1 E7.5_Meso.1.1
SRR3083919 RNA-Seq 252 3313845108 PRJNA307584 SAMN04383640 1674695388 GEO public sra,fastq s3 s3.us-east-1 E7.5_Meso SRX1515389 GSM2027223 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027223 postimplantation embryo_E7.5 Mesoderm SRP068043 Mesoderm C57BL/6N x DBA/2N E7.5 1 2 E7.5_Meso.2.1
SRR3083920 RNA-Seq 252 3166405704 PRJNA307584 SAMN04383641 1593347681 GEO public sra,fastq s3 s3.us-east-1 E7.5_Endo SRX1515390 GSM2027224 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027224 postimplantation embryo_E7.5 Endoderm SRP068043 Endoderm C57BL/6N x DBA/2N E7.5 1 1 E7.5_Endo.1.1
SRR3083921 RNA-Seq 252 3315087972 PRJNA307584 SAMN04383642 1648299193 GEO public fastq,sra s3 s3.us-east-1 E7.5_Endo SRX1515391 GSM2027225 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027225 postimplantation embryo_E7.5 Endoderm SRP068043 Endoderm C57BL/6N x DBA/2N E7.5 1 2 E7.5_Endo.2.1
SRR3083899 RNA-Seq 252 4573808316 PRJNA307584 SAMN04383622 2348348323 GEO public sra,fastq s3 s3.us-east-1 E3.5_TE SRX1515372 GSM2027206 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027206 Preimplantation embryo_E3.5 Trophectoderm SRP068043 Trophectoderm C57BL/6N x DBA/2N E3.5 1 1 E3.5_TE.1.1
SRR3083900 RNA-Seq 252 2453314500 PRJNA307584 SAMN04383623 1259848009 GEO public sra,fastq s3 s3.us-east-1 E3.5_TE SRX1515373 GSM2027207 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027207 Preimplantation embryo_E3.5 Trophectoderm SRP068043 Trophectoderm C57BL/6N x DBA/2N E3.5 1 2 E3.5_TE.2.1
SRR3083907 RNA-Seq 202 3102069762 PRJNA307584 SAMN04383628 1877357554 GEO public fastq,sra s3 s3.us-east-1 E5.5_VE SRX1515378 GSM2027212 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027212 postimplantation embryo_E5.5 Visceral endoderm SRP068043 Visceral endoderm C57BL/6N x DBA/2N E5.5 1 1 E5.5_VE.1.1
SRR3083908 RNA-Seq 202 2516721232 PRJNA307584 SAMN04383629 1578950954 GEO public fastq,sra s3 s3.us-east-1 E5.5_VE SRX1515379 GSM2027213 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027213 postimplantation embryo_E5.5 Visceral endoderm SRP068043 Visceral endoderm C57BL/6N x DBA/2N E5.5 1 2 E5.5_VE.2.1
SRR3083911 RNA-Seq 252 2131346448 PRJNA307584 SAMN04383632 1048919276 GEO public sra,fastq s3 s3.us-east-1 E6.5_VE SRX1515382 GSM2027216 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027216 postimplantation embryo_E6.5 Visceral endoderm SRP068043 Visceral endoderm C57BL/6N x DBA/2N E6.5 1 1 E6.5_VE.1.1
SRR3083912 RNA-Seq 202 1378475876 PRJNA307584 SAMN04383632 965913799 GEO public fastq,sra s3 s3.us-east-1 E6.5_VE SRX1515382 GSM2027216 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027216 postimplantation embryo_E6.5 Visceral endoderm SRP068043 Visceral endoderm C57BL/6N x DBA/2N E6.5 2 1 E6.5_VE.1.2
SRR3083913 RNA-Seq 202 3161247884 PRJNA307584 SAMN04383633 2237835407 GEO public fastq,sra s3 s3.us-east-1 E6.5_VE SRX1515383 GSM2027217 Illumina HiSeq 1500 PAIRED cDNA TRANSCRIPTOMIC Mus musculus ILLUMINA 2017-12-06 GSM2027217 postimplantation embryo_E6.5 Visceral endoderm SRP068043 Visceral endoderm C57BL/6N x DBA/2N E6.5 1 2 E6.5_VE.2.1

Lineplot

The plotted blastocyst expression value is the highest value shown by that gene between E3.5 ICM and E3.5 trophectoderm samples.

Of note, most of the plasma membrane/stress fibers-related DEGs are highly expressed in the blastocyst trophectoderm:

sessionInfo()
## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.6 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=it_IT.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=it_IT.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=it_IT.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=it_IT.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] ggpubr_0.5.0                data.table_1.14.6          
##  [3] reshape2_1.4.4              ggplot2_3.4.0              
##  [5] tximport_1.22.0             DESeq2_1.34.0              
##  [7] SummarizedExperiment_1.24.0 Biobase_2.54.0             
##  [9] MatrixGenerics_1.6.0        matrixStats_0.62.0         
## [11] GenomicRanges_1.46.1        GenomeInfoDb_1.30.1        
## [13] IRanges_2.28.0              S4Vectors_0.32.4           
## [15] BiocGenerics_0.40.0        
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-3       ggsignif_0.6.4         deldir_1.0-6          
##   [4] ellipsis_0.3.2         htmlTable_2.4.1        XVector_0.34.0        
##   [7] base64enc_0.1-3        rstudioapi_0.14        farver_2.1.1          
##  [10] bit64_4.0.5            AnnotationDbi_1.56.2   fansi_1.0.3           
##  [13] codetools_0.2-18       splines_4.1.3          cachem_1.0.6          
##  [16] geneplotter_1.72.0     knitr_1.40             Formula_1.2-4         
##  [19] jsonlite_1.8.3         broom_1.0.1            annotate_1.72.0       
##  [22] cluster_2.1.2          png_0.1-7              readr_2.1.3           
##  [25] compiler_4.1.3         httr_1.4.4             backports_1.4.1       
##  [28] assertthat_0.2.1       Matrix_1.5-3           fastmap_1.1.0         
##  [31] cli_3.4.1              htmltools_0.5.3        tools_4.1.3           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.7
##  [37] dplyr_1.0.10           Rcpp_1.0.9             carData_3.0-5         
##  [40] jquerylib_0.1.4        vctrs_0.5.1            Biostrings_2.62.0     
##  [43] xfun_0.35              stringr_1.4.1          lifecycle_1.0.3       
##  [46] rstatix_0.7.1          XML_3.99-0.12          zlibbioc_1.40.0       
##  [49] scales_1.2.1           vroom_1.6.0            hms_1.1.2             
##  [52] parallel_4.1.3         RColorBrewer_1.1-3     yaml_2.3.6            
##  [55] gridExtra_2.3          memoise_2.0.1          sass_0.4.2            
##  [58] rpart_4.1.16           latticeExtra_0.6-30    stringi_1.7.8         
##  [61] RSQLite_2.2.18         highr_0.9              genefilter_1.76.0     
##  [64] checkmate_2.1.0        BiocParallel_1.28.3    rlang_1.0.6           
##  [67] pkgconfig_2.0.3        bitops_1.0-7           evaluate_0.18         
##  [70] lattice_0.20-45        purrr_0.3.5            labeling_0.4.2        
##  [73] htmlwidgets_1.5.4      bit_4.0.5              tidyselect_1.2.0      
##  [76] plyr_1.8.8             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         Hmisc_4.7-2            DelayedArray_0.20.0   
##  [82] DBI_1.1.3              pillar_1.8.1           foreign_0.8-82        
##  [85] withr_2.5.0            survival_3.2-13        KEGGREST_1.34.0       
##  [88] abind_1.4-5            RCurl_1.98-1.9         nnet_7.3-17           
##  [91] tibble_3.1.8           crayon_1.5.2           car_3.1-1             
##  [94] interp_1.1-3           utf8_1.2.2             tzdb_0.3.0            
##  [97] rmarkdown_2.18         jpeg_0.1-9             locfit_1.5-9.6        
## [100] grid_4.1.3             blob_1.2.3             digest_0.6.30         
## [103] xtable_1.8-4           tidyr_1.2.1            munsell_0.5.0         
## [106] bslib_0.4.1